Safety and intestinal tolerance of high-dose enteral antioxidants and glutamine peptides after upper gastrointestinal surgery

Details

Serval ID
serval:BIB_48AD9F5AC4C4
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Safety and intestinal tolerance of high-dose enteral antioxidants and glutamine peptides after upper gastrointestinal surgery
Journal
European Journal of Clinical Nutrition
Author(s)
Schroeder  J., Alteheld  B., Stehle  P., Cayeux  M. C., Chiolero  R. L., Berger  M. M.
ISSN
0954-3007 (Print)
Publication state
Published
Issued date
02/2005
Volume
59
Number
2
Pages
307-10
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Feb
Abstract
OBJECTIVE: Safety and intestinal tolerance of an early high-dose enteral administration of antioxidative vitamins, trace elements, and glutamine dipeptides. DESIGN: open intervention trial. SETTING: Two university teaching hospitals. PATIENTS: A total of 14 patients requiring jejunal feeding (64+/-14 y). INTERVENTION: A measure of 500 ml/day Intestamin (FreseniusKabi: 250 kcal/1.050 kJ, 300 microg selenium, 20 mg zinc, 400 mug chromium, 1500 mg vitamin C, 500 mg vitamin E, 10 mg beta-carotene, 30 g glutamine) for 5 days beginning 6 h after surgery. Parenteral/enteral nutrition was provided to achieve energy target (25 kcal/kg/day). ASSESSMENTS: Intestinal complaints, plasma nutrients, and glutathione. RESULTS: Only minor signs of nausea, hiccups, flatulence (3/14). Plasma micronutrients (except beta-carotene) postoperatively decreased and increased to normal on day 5. Extracellular glutamine remained low (preop: 520+/-94; d1: 357+/-67; d5: 389+/-79 micromol/l); total glutathione decreased (d1: 9.4+/-3.8; d5: 3.6+/-2.5 micromol/l). CONCLUSION: Study feed is well tolerated and metabolically safe representing a valuable tool for targeted pharmaconutrient supply.
Keywords
Antioxidants/*administration & dosage/metabolism *Enteral Nutrition Female Food, Formulated/adverse effects Gastrointestinal Neoplasms/surgery/*therapy Glutamine/*administration & dosage/metabolism Humans Intestinal Absorption Jejunostomy Male Middle Aged Postoperative Care/methods Safety Time Factors Trace Elements/*administration & dosage/metabolism Treatment Outcome
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 16:52
Last modification date
20/08/2019 13:55
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