Prenatal diagnosis and epidemiology of multicystic kidney dysplasia in Europe.

Details

Serval ID
serval:BIB_48937C300864
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Prenatal diagnosis and epidemiology of multicystic kidney dysplasia in Europe.
Journal
Prenatal Diagnosis
Author(s)
Winding L., Loane M., Wellesley D., Addor M.C., Arriola L., Bakker M.K., Bianchi F., Calzolari E., Gatt M., Haeusler M., Lelong N., Mullaney C., Scarano G., Tucker D., Wiesel A., Garne E.
ISSN
1097-0223 (Electronic)
ISSN-L
0197-3851
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
34
Number
11
Pages
1093-1098
Language
english
Notes
Publication types: Publication Status: ppublish
Abstract
OBJECTIVES: The aim of this study is to describe the prenatal diagnosis and epidemiology of multicystic kidney dysplasia (MCKD).
METHODS: The study is based on routinely collected data from a European database of major congenital anomalies including 13 registries with cases born in 1997-2006 and covering 1 458 552 births.
RESULTS: There were 601 MCKD cases giving an overall prevalence of 4.12 per 10 000 births with regional variation. In live births, 87% of cases had an isolated renal anomaly and 13% had associated major nonrenal anomalies (chromosomal, syndrome or other major anomalies). For the cases with isolated renal anomalies, 51/386 (11%) and 7/386 (2%) choose to terminate the pregnancy or resulted in an intrauterine fetal death, respectively. The prenatal detection rate was 88% in both unilateral and bilateral cases. Birth outcome differed with 92% of unilateral MCKD cases being liveborn compared with 33% of bilateral MCKD cases. For unilateral MCKD cases, 84% had an isolated renal anomaly compared with 51% of bilateral MCKD cases (p < 0.001).
CONCLUSIONS: Cases with unilateral MCKD are mainly liveborn, and only 16% have associated major malformations or a syndrome. Cases with bilateral MCKD are often associated with nonrenal major congenital anomalies or part of a syndrome, and only one third of bilateral MCKD cases in this study were liveborn. Prenatal detection rate of MCKD was high for both unilateral and bilateral cases. © 2014 John Wiley & Sons, Ltd.
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Web of science
Create date
18/12/2014 18:36
Last modification date
20/08/2019 13:55
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