Fetal lung hypoplasia associated with maternal smoking: a morphometric analysis

Details

Serval ID
serval:BIB_48896143F19E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Fetal lung hypoplasia associated with maternal smoking: a morphometric analysis
Journal
Pediatric Research
Author(s)
Collins  M. H., Moessinger  A. C., Kleinerman  J., Bassi  J., Rosso  P., Collins  A. M., James  L. S., Blanc  W. A.
ISSN
0031-3998 (Print)
Publication state
Published
Issued date
04/1985
Volume
19
Number
4
Pages
408-12
Notes
Journal Article
Research Support, U.S. Gov't, P.H.S. --- Old month value: Apr
Abstract
Our recently reported animal (rat) model of maternal cigarette smoke exposure during pregnancy is characterized by fetal growth retardation and lung hypoplasia. We have further defined the fetal lungs using quantitative histologic techniques. Compared to controls, lung volume at term is reduced in the experimental animals (0.28 versus 0.33 ml, p less than 0.005). Saccules (fetal "alveoli") are reduced in number (3 X 10(6) versus 5.5 X 10(6), p less than 0.005) and increased in size (average saccular volume: 35 X 10(-9) versus 21 X 10(-9) ml, p less than 0.025). These changes in size and number are consequences of reduced formation of saccule partitions (septal crests) in the experimental lungs (volume density: 0.013 versus 0.018, p less than 0.025). Internal surface area is decreased in the hypoplastic lungs (161 versus 198 cm2, p less than 0.001). The total length of parenchymal elastic tissue is diminished (224 versus 354 M, p less than 0.05). In short the hypoplastic lungs contain fewer, larger saccules and the surface potentially available for gas exchange is reduced. These results show that maternal smoking in rats adversely modifies fetal lung growth. If these observations are applicable to humans, then reduced lung growth in children of smoking mothers may begin antenatally.
Keywords
Animals Elastic Tissue/pathology Female *Fetus Lung/*abnormalities/pathology Organ Size Pregnancy Rats Rats, Inbred Strains *Smoking
Pubmed
Web of science
Create date
25/01/2008 13:16
Last modification date
20/08/2019 13:55
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