Aryl hydrocarbon receptor controls regulatory CD4+ T cell function.

Details

Serval ID
serval:BIB_4887BAEE2676
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Aryl hydrocarbon receptor controls regulatory CD4+ T cell function.
Journal
Swiss medical weekly
Author(s)
Pot C.
ISSN
1424-3997 (Electronic)
ISSN-L
0036-7672
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
142
Pages
w13592
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: epublish
Abstract
The ligand activated transcription factor aryl hydrocarbon receptor (AhR) has been studied for many decades in toxicology as the ligand for the environmental contaminant dioxin. However, AhR has recently emerged as a critical physiological regulator of immune responses affecting both innate and adaptive systems, and several AhR ligands with different pharmacological profiles have recently been studied. The current review discusses new insights into the role of AhR signalling and AhR ligands on the regulation of the immune system, with a focus on regulatory T cells which maintain immune tolerance. Notably, AhR is expressed and modulates the development of two induced regulatory CD4+ T cell subsets, the forkhead box P3-positive (Foxp3+) regulatory T cells (iTreg) and the IL-10-secreting type 1 regulatory T (T(R)1) cells, through different signalling pathways. We will finally discuss how AhR ligands could be exploited to alleviate human autoimmune diseases. Clearly, drugs targeted against AhR should promote the development of new strategies to fight against autoimmune diseases.
Keywords
Autoimmune Diseases/drug therapy, Autoimmune Diseases/metabolism, CD4-Positive T-Lymphocytes/metabolism, Forkhead Transcription Factors/immunology, Forkhead Transcription Factors/metabolism, Humans, Interleukin-10/immunology, Interleukin-10/metabolism, Ligands, Receptors, Aryl Hydrocarbon/immunology, Receptors, Aryl Hydrocarbon/metabolism
Pubmed
Web of science
Open Access
Yes
Create date
21/08/2018 16:05
Last modification date
20/08/2019 13:55
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