Early appearance of bactericidal antibodies after polysaccharide challenge of toddlers primed with a group C meningococcal conjugate vaccine: what is its role in the maintenance of protection?

Details

Serval ID
serval:BIB_4886A673CCAB
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Early appearance of bactericidal antibodies after polysaccharide challenge of toddlers primed with a group C meningococcal conjugate vaccine: what is its role in the maintenance of protection?
Journal
Clinical and Vaccine Immunology
Author(s)
Tsai  T. F., Borrow  R., Gnehm  H. E., Vaudaux  B., Heininger  U., Desgrandchamps  D., Aebi  C., Balmer  P., Pedersen  R. D., Fritzell  B., Siegrist  C. A.
ISSN
1556-6811 (Print)
Publication state
Published
Issued date
08/2006
Volume
13
Number
8
Pages
854-61
Notes
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't --- Old month value: Aug
Abstract
The contribution of memory responses after meningococcal vaccination to protection may depend on the rapidity of the response. Toddlers were challenged with a licensed polysaccharide (PS) vaccine 1 year after vaccination with a single dose of meningococcal group C-CRM(197) conjugate (MCC) vaccine at the age of 12 to 15 months. Bactericidal antibodies and immunoglobulin G (IgG) antibodies detected by an enzyme-linked immunosorbent assay (ELISA) were measured before challenge and 4, 7, 14, or 21 Days later ("Days" refer to treatment groups, "days" to sampling days). Among 281 subjects in the intent-to-treat population, 173 per-protocol (PP) subjects were challenged with 10 microg PS antigen and 103 others with a 50-microg PS vaccinating dose. Capsular PS-specific ELISA IgG titers were negligible in baseline samples and increased only twofold within 4 days of PS administration. In contrast, the proportion of PP subjects with serum bactericidal antibody (SBA) titers of >or=1:8 or >or=1:128 increased, respectively, from 41% and 16% before challenge to 84% and 74% at Day 4 and to 100% and 97% at Day 7. Recipients of 50 microg PS responded with similar kinetics but showed a trend toward higher antibody levels. Unexpectedly, 69% of subjects bled on days 2 to 3 already had achieved SBA titers of >or=1:8. The majority of toddlers previously immunized with MCC and challenged 1 year later with PS antigen mounted protective levels of bactericidal antibody within 2 to 4 days.
Keywords
Antibodies, Bacterial/*blood Female Humans Immunoglobulin G/blood/immunology *Immunologic Memory Infant Male Meningitis, Meningococcal/immunology/*prevention & control Meningococcal Vaccines/adverse effects/immunology/*therapeutic use Polysaccharides, Bacterial/immunology/*pharmacology Prospective Studies Switzerland Time Factors Treatment Outcome Vaccines, Conjugate/adverse effects/immunology/*therapeutic use
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 10:33
Last modification date
20/08/2019 13:55
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