Improving outcomes for solid-organ transplant recipients at risk from cytomegalovirus infection: late-onset disease and indirect consequences

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Serval ID
serval:BIB_4883DFD8A7E5
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Improving outcomes for solid-organ transplant recipients at risk from cytomegalovirus infection: late-onset disease and indirect consequences
Journal
Clinical Infectious Diseases
Author(s)
Legendre C., Pascual M.
ISSN
1537-6591[electronic]
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
46
Number
5
Pages
732-740
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review - Publication Status: ppublish
Abstract
Cytomegalovirus (CMV) is one of the most important pathogens following solid-organ transplantation, and effective prevention of CMV infection is a priority. The long-term control of CMV infection is dependent, in part, on the development of CMV-specific T cells, and controversy exists regarding whether CMV prophylaxis may prevent this. Although preemptive therapy is beneficial for the prevention of CMV disease, monitoring of viral levels in the blood does not always reflect what is occurring in tissues. Persistent low-level CMV infection has been associated with indirect consequences, such as transplant-associated vasculopathy, posttransplantation diabetes, an increased risk of opportunistic infection, and graft rejection. The issues surrounding preventive strategies for CMV disease following solid-organ transplantation are reviewed. We argue that prophylaxis is more effective than preemptive therapy; extending the duration of prophylaxis to the period of less intense immunosuppression could protect patients from late-onset disease, as well as from the indirect effects of CMV infection.
Keywords
Antiviral Agents, Chemoprevention, Cytomegalovirus Infections, Humans, Organ Transplantation, Postoperative Complications
Pubmed
Web of science
Open Access
Yes
Create date
19/02/2008 18:09
Last modification date
24/09/2019 8:49
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