Does large oversizing of self-expandable endoprostheses compensate for aortic growth?

Details

Serval ID
serval:BIB_483C5948CF0C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Does large oversizing of self-expandable endoprostheses compensate for aortic growth?
Journal
Journal of Vascular Surgery
Author(s)
Marty  B., Maeder  B., Gallino  A., Mucciolo  A., von Segesser  L. K.
ISSN
0741-5214 (Print)
Publication state
Published
Issued date
12/2003
Volume
38
Number
6
Pages
1368-75
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Dec
Abstract
PURPOSE: There is experimental evidence that self-expandable endoprostheses are appropriate for compensation of aortic growth. A potential future application includes their use in the treatment of aortic coarctation. Yet their behavior is poorly investigated. The present study evaluates the performance of largely oversized self-expandable endoprostheses (EPs) in the growing porcine aorta and the biologic response toward them. METHODS: Twenty oversized EPs (Talent, TalentLoPro, Stenway, and Wallstent; nominal lumen area 314 mm(2) [diameter 20 mm]) were implanted in the descending thoracic aorta of juvenile pigs. Four nonoversized EPs (TalentLoPro; nominal lumen area 154 mm(2) [diameter 14 mm]) served as controls. Cross sections of aorta and EPs were measured by intravascular ultrasound (IVUS) at implantation and 3 months follow-up. The histologic response was assessed by microscopy. RESULTS: At implantation, the EPs were 99 +/- 41% oversized relative to the aortic area [48 +/- 22% in diameter]. At follow-up, the area of the aortic lumen increased 60 +/- 50%, P <.001 [29 +/- 23% in diameter]. The Stenway EPs demonstrated the largest prosthetic lumen with 80 +/- 10% of their nominal area (P =.001). However, the prosthetic lumen area was reduced by intimal hyperplasia in all devices. The largest perfused lumen was obtained by the TalentLoPro EPs due to their progressive expansion. Nonoversized EPs resulted in a significantly smaller perfused lumen (P =.012). The inflammatory response to polyester was moderate, whereas polyurethane evoked an extensive body-foreign reaction. CONCLUSION: Large oversizing of self-expandable EPs is essential in order to maintain a large perfused lumen during aortic growth, thereby minimizing the adverse effect of intimal hyperplasia. This was best achieved by the TalentLoPro EPs.
Keywords
Animals Aorta, Thoracic/*growth & development/pathology/surgery *Blood Vessel Prosthesis/adverse effects Blood Vessel Prosthesis Implantation Disease Models, Animal Endothelium, Vascular/*growth & development/pathology/surgery Hyperplasia/etiology/pathology Prosthesis Design Swine
Pubmed
Web of science
Create date
28/01/2008 9:31
Last modification date
20/08/2019 13:55
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