Molecular and immunological evaluation of the expression of cancer/testis gene products in human colorectal cancer.

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Ressource 1Download: serval:BIB_483359E44050.P001 (473.07 [Ko])
State: Public
Version: author
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It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_483359E44050
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Molecular and immunological evaluation of the expression of cancer/testis gene products in human colorectal cancer.
Journal
Cancer immunology, immunotherapy
Author(s)
Alves P.M., Lévy N., Bouzourene H., Viatte S., Bricard G., Ayyoub M., Vuilleumier H., Givel J.C., Halkic N., Speiser D.E., Romero P., Lévy F.
ISSN
0340-7004
Publication state
Published
Issued date
2007
Peer-reviewed
Oui
Volume
56
Number
6
Pages
839-847
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Tumor-specific gene products, such as cancer/testis (CT) antigens, constitute promising targets for the development of T cell vaccines. Whereas CT antigens are frequently expressed in melanoma, their expression in colorectal cancers (CRC) remains poorly characterized. Here, we have studied the expression of the CT antigens MAGE-A3, MAGE-A4, MAGE-A10, NY-ESO-1 and SSX2 in CRC because of the presence of well-described HLA-A2-restricted epitopes in their sequences. Our analyses of 41 primary CRC and 14 metastatic liver lesions confirmed the low frequency of expression of these CT antigens. No increased expression frequencies were observed in metastatic tumors compared to primary tumors. Histological analyses of CRC samples revealed heterogeneous expression of individual CT antigens. Finally, evidence of a naturally acquired CT antigen-specific CD8(+) T cell response could be demonstrated. These results show that the expression of CT antigens in a subset of CRC patients induces readily detectable T cell responses.
Keywords
Antigens, Neoplasm/biosynthesis, Antigens, Neoplasm/genetics, CD8-Positive T-Lymphocytes/immunology, Colorectal Neoplasms/genetics, Colorectal Neoplasms/immunology, Gene Expression, Gene Expression Profiling, Humans, Immunohistochemistry, Liver Neoplasms/metabolism, Liver Neoplasms/secondary, Male, Neoplasm Proteins/biosynthesis, Neoplasm Proteins/genetics, Reverse Transcriptase Polymerase Chain Reaction
Pubmed
Web of science
Open Access
Yes
Create date
28/01/2008 11:17
Last modification date
01/10/2019 6:17
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