Increased prevalence of clonal hematopoiesis of indeterminate potential amongst people living with HIV.

Details

Serval ID
serval:BIB_482297EB27F3
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Increased prevalence of clonal hematopoiesis of indeterminate potential amongst people living with HIV.
Journal
Scientific reports
Author(s)
Bick A.G., Popadin K., Thorball C.W., Uddin M.M., Zanni M.V., Yu B., Cavassini M., Rauch A., Tarr P., Schmid P., Bernasconi E., Günthard H.F., Libby P., Boerwinkle E., McLaren P.J., Ballantyne C.M., Grinspoon S., Natarajan P., Fellay J.
Working group(s)
Swiss HIV Cohort Study
Contributor(s)
Abela I., Aebi-Popp K., Anagnostopoulos A., Battegay M., Bernasconi E., Braun D.L., Bucher H.C., Calmy A., Cavassini M., Ciuffi A., Dollenmaier G., Egger M., Elzi L., Fehr J., Fellay J., Furrer H., Fux C.A., Günthard H.F., Hachfeld A., Haerry D., Hasse B., Hirsch H.H., Hoffmann M., Hösli I., Huber M., Kahlert C.R., Kaiser L., Keiser O., Klimkait T., Kouyos R.D., Kovari H., Kusejko K., Martinetti G., de Tejada B.M., Marzolini C., Metzner K.J., Müller N., Nemeth J., Nicca D., Paioni P., Pantaleo G., Perreau M., Rauch A., Schmid P., Speck R., Stöckle M., Tarr P., Trkola A., Wandeler G., Yerly S.
ISSN
2045-2322 (Electronic)
ISSN-L
2045-2322
Publication state
Published
Issued date
12/01/2022
Peer-reviewed
Oui
Volume
12
Number
1
Pages
577
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
People living with human immunodeficiency virus (PLWH) have significantly increased risk for cardiovascular disease in part due to inflammation and immune dysregulation. Clonal hematopoiesis of indeterminate potential (CHIP), the age-related acquisition and expansion of hematopoietic stem cells due to leukemogenic driver mutations, increases risk for both hematologic malignancy and coronary artery disease (CAD). Since increased inflammation is hypothesized to be both a cause and consequence of CHIP, we hypothesized that PLWH have a greater prevalence of CHIP. We searched for CHIP in multi-ethnic cases from the Swiss HIV Cohort Study (SHCS, n = 600) and controls from the Atherosclerosis Risk in the Communities study (ARIC, n = 8111) from blood DNA-derived exome sequences. We observed that HIV is associated with a twofold increase in CHIP prevalence, both in the whole study population and in a subset of 230 cases and 1002 matched controls selected by propensity matching to control for demographic imbalances (SHCS 7%, ARIC 3%, p = 0.005). We also observed that ASXL1 is the most commonly mutated CHIP-associated gene in PLWH. Our results suggest that CHIP may contribute to the excess cardiovascular risk observed in PLWH.
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2022 8:30
Last modification date
29/01/2022 7:33
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