Correlation of intra- and extraepidermal CD8 T cell numbers with development of psoriatic epidermal pathology

Details

Serval ID
serval:BIB_47FE33B4E874
Type
Inproceedings: an article in a conference proceedings.
Publication sub-type
Abstract (Abstract): shot summary in a article that contain essentials elements presented during a scientific conference, lecture or from a poster.
Collection
Publications
Institution
Title
Correlation of intra- and extraepidermal CD8 T cell numbers with development of psoriatic epidermal pathology
Title of the conference
Annual Meeting of the Society for Investigative Dermatology
Author(s)
Navarini A., Tonel G., Conrad C.
Address
Phoenix, Arizona, May 4-7, 2011
ISBN
0022-202X
Publication state
Published
Issued date
2011
Volume
131
Series
Journal of Investigative Dermatology
Pages
S100
Language
english
Notes
Publication type : Meeting Abstract
Abstract
The development of psoriatic plaques is T cell dependent. Recently, Th17 CD4 T cells have been proposed to be the main effector cells. However, development of psoriasis is critically dependent on accumulation of epidermal T cells, among the majority express CD8. Here we show that numbers of epidermal CD8 T cells correlated with development of psoriasis in human biopsies, and that blockade of CD8 T cells by depleting antibodies inhibited development of psoriasis in the AGR xenotransplantation mouse model. In human dermis, both CD4 and CD8 T cell numbers correlated significantly with epidermal pathology, indicating a role for dermal CD4 T cells in orchestrating the development of psoriasiform changes induced by epidermis-infiltrating CD8 T cells.
Keywords
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Web of science
Create date
06/05/2011 14:06
Last modification date
20/08/2019 13:54
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