Worldwide Population Structure, Long-Term Demography, and Local Adaptation of Helicobacter pylori.

Details

Serval ID
serval:BIB_47F6F7C61DFD
Type
Article: article from journal or magazin.
Collection
Publications
Title
Worldwide Population Structure, Long-Term Demography, and Local Adaptation of Helicobacter pylori.
Journal
Genetics
Author(s)
Montano V., Didelot X., Foll M., Linz B., Reinhardt R., Suerbaum S., Moodley Y., Jensen J.D.
ISSN
1943-2631 (Electronic)
ISSN-L
0016-6731
Publication state
Published
Issued date
2015
Volume
200
Number
3
Pages
947-963
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Helicobacter pylori is an important human pathogen associated with serious gastric diseases. Owing to its medical importance and close relationship with its human host, understanding genomic patterns of global and local adaptation in H. pylori may be of particular significance for both clinical and evolutionary studies. Here we present the first such whole genome analysis of 60 globally distributed strains, from which we inferred worldwide population structure and demographic history and shed light on interesting global and local events of positive selection, with particular emphasis on the evolution of San-associated lineages. Our results indicate a more ancient origin for the association of humans and H. pylori than previously thought. We identify several important perspectives for future clinical research on candidate selected regions that include both previously characterized genes (e.g., transcription elongation factor NusA and tumor necrosis factor alpha-inducing protein Tipα) and hitherto unknown functional genes.
Keywords
Adaptation, Physiological/genetics, Genetic Variation, Genome, Bacterial, Genomics, Helicobacter Infections/microbiology, Helicobacter pylori/genetics, Helicobacter pylori/physiology, Humans, Phylogeography, Selection, Genetic
Pubmed
Web of science
Create date
10/08/2015 11:41
Last modification date
20/08/2019 14:54
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