Identification of Alzheimer and vascular lesion thresholds for mixed dementia

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Serval ID
serval:BIB_47D13F82FE4D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Identification of Alzheimer and vascular lesion thresholds for mixed dementia
Journal
Brain
Author(s)
Gold Gabriel, Giannakopoulos Panteleimon, Herrmann François R., Bouras Constantin, Kövari Enikö
ISSN
0006-8950
Publication state
Published
Issued date
2007
Peer-reviewed
Oui
Volume
130
Number
11
Pages
2830-2836
Language
english
Notes
SAPHIRID:64354
Abstract
To explore the pathological substrates of mixed dementia, we performed a detailed analysis of lacunar and microvascular pathology in 156 autopsied, elderly individuals with various degrees of Alzheimer's disease (AD) pathology. Cognitive status was assessed prospectively using the Clinical Dementia Rating (CDR) scale; neuropathological evaluation included Braak neurofibrillary tangle (NFT) and Ass-protein deposition staging and bilateral semi-quantitative assessment of microvascular ischaemic pathology and lacunes; statistics included univariate and multiple regression models controlling for age, and receiver-operating characteristic analysis. Sensitivity analysis was performed in a randomized derivation sub-sample and tested in a validation sub-sample. White matter lacunes, periventricular and diffuse white matter demyelination and focal and diffuse cortical gliosis were not associated with cognition. Braak NFT, Ass deposition, cortical microinfarcts (CMI) and thalamic and basal ganglia lacunes (TBGL) predicted 27% of CDR variability and 49% of the presence of dementia. Braak NFT, CMI and TBGL thresholds determined in a derivation sample yielded 0.88 sensitivity, 0.79 specificity and 0.85 correct classification rate for dementia in a validation sample. The same thresholds distinguished three groups of demented cases consistent with mixed dementia, pure vascular dementia and AD. These findings indicate that the clinical expression of the vascular component in mixed cases is highly dependent on lesion type and location as well as severity of concomitant AD-related pathology. Proposed thresholds for vascular and degenerative lesions predict the presence of dementia with great accuracy and provide a basis for distinguishing pure vascular dementia or AD from mixed cases.
Pubmed
Web of science
Open Access
Yes
Create date
10/03/2008 11:04
Last modification date
25/09/2019 6:09
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