Sub-minute prediction of brain temperature based on sleep-wake state in the mouse.

Details

Serval ID
serval:BIB_47C4B87EDABE
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Sub-minute prediction of brain temperature based on sleep-wake state in the mouse.
Journal
eLife
Author(s)
Sela Y., Hoekstra M.M., Franken P.
ISSN
2050-084X (Electronic)
ISSN-L
2050-084X
Publication state
Published
Issued date
08/03/2021
Peer-reviewed
Oui
Volume
10
Pages
e62073
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Although brain temperature has neurobiological and clinical importance, it remains unclear which factors contribute to its daily dynamics and to what extent. Using a statistical approach, we previously demonstrated that hourly brain temperature values co-varied strongly with time spent awake (Hoekstra et al., 2019). Here we develop and make available a mathematical tool to simulate and predict cortical temperature in mice based on a 4-s sleep-wake sequence. Our model estimated cortical temperature with remarkable precision and accounted for 91% of the variance based on three factors: sleep-wake sequence, time-of-day ('circadian'), and a novel 'prior wake prevalence' factor, contributing with 74%, 9%, and 43%, respectively (including shared variance). We applied these optimized parameters to an independent cohort of mice and predicted cortical temperature with similar accuracy. This model confirms the profound influence of sleep-wake state on brain temperature, and can be harnessed to differentiate between thermoregulatory and sleep-wake-driven effects in experiments affecting both.
Keywords
brain temperature, computational biology, mice, model, mouse, neuroscience, sleep-wake state, systems biology
Pubmed
Web of science
Open Access
Yes
Create date
16/03/2021 9:19
Last modification date
04/04/2021 6:37
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