SBRT and extreme hypofractionation: A new era in prostate cancer treatments?

Details

Serval ID
serval:BIB_47AFDD9A5823
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
SBRT and extreme hypofractionation: A new era in prostate cancer treatments?
Journal
Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology
Author(s)
Alongi F., Fiorentino A., De Bari B.
ISSN
1507-1367 (Print)
ISSN-L
1507-1367
Publication state
Published
Issued date
2015
Volume
20
Number
6
Pages
411-416
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Radiation therapy (RT) is a standard therapeutic option for prostate cancer (PC). In the last decades, several innovative technology applications have been introduced. 3-Dimensional conformal RT, volumetric/rotational intensity modulated RT associated or not with image-guided RT, are becoming largely diffused in the treatment of PC.
Considering that PC could have a low α/β ratio, similar to late-reacting normal tissues, it could also be highly responsive to fraction size. Thus, the reduction of the number of fractions and the increase of the dose/fraction seem to be reasonable choices in the treatment of this cancer. This review reported the technology evolution, the radiobiological and the clinical data about the role of extreme hypofractionated RT in the treatment approach of PC patients.
Medline search and analysis of published studies containing key words: prostate cancer, radiotherapy, stereotactic radiotherapy.
Recent technological developments, combined with an improved knowledge of the radiobiological models in favor of a high sensitivity of PC to larger fraction sizes are opening a new scenario in its treatment, reporting favorable efficacy and acceptable toxicity, despite short follow-up.
Thus, thanks to technological improvement and the recent radiobiological data, "extreme hypofractionated RT" has been strongly introduced in the last years as a potential solid treatment option for PC.

Pubmed
Create date
14/02/2017 12:51
Last modification date
03/03/2018 16:50
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