Neuroprotection for optic nerve disorders.

Details

Serval ID
serval:BIB_479646DF17E0
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Neuroprotection for optic nerve disorders.
Journal
Current opinion in neurology
Author(s)
Bessero A.C., Clarke P.G.
ISSN
1473-6551 (Electronic)
ISSN-L
1350-7540
Publication state
Published
Issued date
02/2010
Peer-reviewed
Oui
Volume
23
Number
1
Pages
10-15
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
The concept that optic nerve fiber loss might be reduced by neuroprotection arose in the mid 1990s. The subsequent research effort, focused mainly on rodent models, has not yet transformed into a successful clinical trial, but provides mechanistic understanding of retinal ganglion cell death and points to potential therapeutic strategies. This review highlights advances made over the last year.
In excitotoxicity and axotomy models retinal ganglion cell death has been shown to result from a complex interaction between retinal neurons and Müller glia, which release toxic molecules including tumor necrosis factor alpha. This counteracts neuroprotection by neurotrophins such as nerve growth factor, which bind to p75NTR receptors on Müller glia stimulating the toxic release. Another negative effect against neurotrophin-mediated protection involves the action of LINGO-1 at trkB brain-derived neurotrophic factor (BDNF) receptors, and BDNF neuroprotection is enhanced by an antagonist to LINGO-1. As an alternative to pharmacotherapy, retinal defences can be stimulated by exposure to infrared radiation.
The mechanisms involved in glaucoma and other optic nerve disorders are being clarified in rodent models, focusing on retrograde degeneration following axonal damage, excitotoxicity and inflammatory/autoimmune mechanisms. Neuroprotective strategies are being refined in the light of the mechanistic understanding.

Keywords
Antioxidants/therapeutic use, Glaucoma/pathology, Glaucoma/prevention & control, Glaucoma/therapy, Humans, Infrared Rays/therapeutic use, Intraocular Pressure, Nitric Oxide Synthase/antagonists & inhibitors, Optic Nerve Diseases/prevention & control, Optic Nerve Diseases/therapy, Retinal Ganglion Cells/pathology, Ubiquinone/analogs & derivatives, Ubiquinone/therapeutic use
Pubmed
Web of science
Create date
21/01/2010 8:54
Last modification date
20/08/2019 13:53
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