HPLC-DAD and HPLC-MS findings in fatality involving (Z)-cis-clopenthixol (zuclopenthixol).

Details

Serval ID
serval:BIB_477D60897878
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Title
HPLC-DAD and HPLC-MS findings in fatality involving (Z)-cis-clopenthixol (zuclopenthixol).
Journal
Journal of Analytical Toxicology
Author(s)
Tracqui A., Kintz P., Cirimele V., Berthault F., Mangin P., Ludes B.
ISSN
0146-4760[print], 0146-4760[linking]
Publication state
Published
Issued date
1997
Volume
21
Number
4
Pages
314-318
Language
english
Abstract
A fatality that was due to massive ingestion of the thioxanthene neuroleptic (Z)-cis-clopenthixol (zuclopenthixol, Z-CPT) is described. The total toxicological screening and the quantitation of both the ingested drugs and its inactive isomer (E)-trans-clopenthixol (E-CPT, produced by in vivo isomerization) in postmortem fluids and viscerae were produced by high-performance liquid chromatography (HPLC)-diode array detection. Drug confirmation was carried out by HPLC-mass spectrometry with an ionspray interface. Although death occurred 40 h after the drug intake, postmortem blood concentrations were 391 and 275 mg/mL for Z-CPT and E-CPT, respectively (50 to 100 times the usual therapeutic values). The cause of death was suicide, and the manner was acute neuroleptic overdosage.
Keywords
Adolescent, Antipsychotic Agents/pharmacokinetics, Antipsychotic Agents/poisoning, Body Fluids/metabolism, Chromatography, High Pressure Liquid/methods, Clopenthixol/pharmacokinetics, Clopenthixol/poisoning, Fatal Outcome, Female, Humans, Mass Spectrometry, Overdose, Tissue Distribution/physiology, Viscera/metabolism
Pubmed
Create date
19/10/2010 16:17
Last modification date
20/08/2019 13:53
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