Immune pressure sculps tumor cells and trims high-quality mutations.

Details

Serval ID
serval:BIB_4774C8AD358C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Immune pressure sculps tumor cells and trims high-quality mutations.
Journal
Cancer cell
Author(s)
Bassani-Sternberg M., Harari A.
ISSN
1878-3686 (Electronic)
ISSN-L
1535-6108
Publication state
Published
Issued date
11/07/2022
Peer-reviewed
Oui
Volume
40
Number
7
Pages
717-719
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Immunoediting, the loss of tumor (neo)antigens due to T cell-dependent selection, sculpts tumor immunogenicity. In Nature, Łuksza et al. conceive a model to score neoantigens' immunogenicity and predict tumor clonal evolution. With this model, they demonstrate that durable tumor control associates with selective limited acquisition of high-quality mutations.
Keywords
Antigens, Neoplasm/genetics, Humans, Mutation, Neoplasms/genetics
Pubmed
Create date
27/07/2022 11:07
Last modification date
06/08/2022 6:36
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