Contribution de l'étude CoLaus à l'élucidation des déterminants de l'acide urique sérique. [Contribution of the CoLaus study to decipher the determinants of serum uric acid].
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Serval ID
serval:BIB_474E8F7C5646
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Contribution de l'étude CoLaus à l'élucidation des déterminants de l'acide urique sérique. [Contribution of the CoLaus study to decipher the determinants of serum uric acid].
Journal
Revue Médicale Suisse
ISSN
1660-9379 (Print)
ISSN-L
1660-9379
Publication state
Published
Issued date
2011
Volume
7
Number
315
Pages
2142, 2144-2142, 2145
Language
french
Abstract
Asymptomatic hyperuricemia affects one in five adults in the general population and is associated with elevated cardiovascular risk. It is however not clear whether asymptomatic hyperuricemia is a cause or simply a marker of conditions associated with high cardiovascular risk. Sex, age, obesity, renal function and selected drugs are major determinants of serum uric acid. Moreover, recent genome-wide association studies have identified new genes involved in the control of serum uric acid levels, in particular SLC2A9, which encodes a urate transporter located in the kidney. A genetic score based on several genetic variants associated with serum uric acid is strongly associated with the risk of gout, but not with cardiovascular events so far.
Keywords
Biological Markers/blood, Cardiovascular Diseases/blood, Cardiovascular Diseases/mortality, Cohort Studies, Glucose Transport Proteins, Facilitative/blood, Gout/blood, Gout/epidemiology, Humans, Hyperuricemia/blood, Hyperuricemia/epidemiology, Risk Factors, Switzerland/epidemiology, Uric Acid/blood
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Create date
07/11/2011 14:36
Last modification date
20/08/2019 14:53
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