Liver ischemia: apoptosis as a central mechanism of injury.

Details

Serval ID
serval:BIB_474D0D8BABE3
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Liver ischemia: apoptosis as a central mechanism of injury.
Journal
Journal of Investigative Surgery
Author(s)
Rüdiger H.A., Graf R., Clavien P.A.
ISSN
0894-1939 (Print)
ISSN-L
0894-1939
Publication state
Published
Issued date
2003
Volume
16
Number
3
Pages
149-159
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Review
Abstract
Injuries due to cold and warm (normothermic) ischemia remain an important source of morbidity and mortality in liver surgery and transplantation. While the mechanisms of injury are complex, involving apoptotic and necrotic types of cell death, accumulating evidence points to a central role for various apoptotic pathways in mediating cell death following ischemia. A number of antiapoptotic strategies have been shown to confer a high degree of protection, including improved animal survival following long ischemic insult. The future may lie in the identification of practical and effective antiapoptotic strategies to enhance tolerance to ischemic injury.
Keywords
Animals, Apoptosis, Humans, Liver Diseases/pathology, Liver Diseases/surgery, Liver Transplantation, Reperfusion Injury/pathology
Pubmed
Web of science
Create date
13/02/2012 8:21
Last modification date
20/08/2019 13:53
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