Primary glomus tumour of the pituitary gland: diagnostic challenges of a rare and potentially aggressive neoplasm.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_4715BD393409
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Primary glomus tumour of the pituitary gland: diagnostic challenges of a rare and potentially aggressive neoplasm.
Journal
Virchows Archiv
Author(s)
Quah B.L., Donofrio C.A., La Rosa S., Brouland J.P., Cossu G., Djoukhadar I., Mayers H., Shenjere P., Pereira M., Pathmanaban O.N., Murtaza M.O., Gattamaneni R., Roncaroli F., Karabatsou K.
ISSN
1432-2307 (Electronic)
ISSN-L
0945-6317
Publication state
In Press
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
Primary non-neuroendocrine tumours of the pituitary gland and sella are rare lesions often challenging to diagnose. We describe two cases of clinically aggressive primary glomus tumour of the pituitary gland. The lesions occurred in a 63-year-old male and a 30-year-old female who presented with headache, blurred vision and hypopituitarism. Neuroimaging demonstrated large sellar and suprasellar tumours invading the surrounding structures. Histologically, the lesions were characterised by angiocentric sheets and nests of atypical cells that expressed vimentin, smooth muscle actin and CD34. Perivascular deposition of collagen IV was also a feature. Case 2 expressed synaptophysin. INI-1 (SMARCB1) expression was preserved. Both lesions were mitotically active and demonstrated a Ki-67 labelling index of 30%. Next-generation sequencing performed in case 1 showed no mutations in the reading frame of 37 commonly mutated oncogenes, including BRAF and KRAS. Four pituitary glomus tumours have previously been reported, none of which showed features of malignant glomus tumour. Similar to our two patients, three previous examples displayed aggressive behaviour.
Keywords
Glomus tumour, Malignant, Non-neuroendocrine tumour, Pituitary gland, Sella
Pubmed
Open Access
Yes
Create date
15/09/2020 14:41
Last modification date
20/09/2020 6:27
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