A t(12;17)(p13;q12) identifies a distinct TEL rearrangement-negative subtype of precursor-B acute lymphoblastic leukemia

Details

Serval ID
serval:BIB_4700ADFD4855
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
A t(12;17)(p13;q12) identifies a distinct TEL rearrangement-negative subtype of precursor-B acute lymphoblastic leukemia
Journal
Cancer Genetics and Cytogenetics
Author(s)
Reid  A. G., Seppa  L., von der Weid  N., Niggli  F. K., Betts  D. R.
ISSN
0165-4608 (Print)
Publication state
Published
Issued date
02/2006
Volume
165
Number
1
Pages
64-9
Notes
Case Reports
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Feb
Abstract
Structural rearrangements involving the short arm of chromosome 12 are common in acute lymphoblastic leukemia (ALL) and often involve the TEL locus at 12p13. The balanced t(12;17)(p13;q12) is a rare but recurrent aberration in ALL. Whereas the TEL gene has been postulated as a likely candidate for involvement in the t(12;17), the precise molecular consequences of this translocation have not yet been elucidated. We identified a t(12;17) in 2 of 398 childhood ALL patients karyotyped at presentation in our institute. Both cases had a precursor-B immunophenotype and were CD10 negative and CD33 positive. Fluorescence in situ hybridization excluded involvement of the TEL locus in the t(12;17) and provided no evidence for concomitant cryptic deletion of the 12p commonly deleted region. Comparison of these and previously published cases demonstrates that the translocation predominately occurs in children and young adults with precursor B-ALL and is typically characterized by low CD10 expression and high CD33 expression. Our data support the involvement of a new locus telomeric to TEL in the pathogenesis of t(12;17)-positive ALL.
Keywords
Adolescent Child Chromosome Banding *Chromosomes, Human, Pair 12 *Chromosomes, Human, Pair 17 Core Binding Factor Alpha 2 Subunit/*genetics *Gene Rearrangement Humans Karyotyping Leukemia, B-Cell, Acute/*genetics Male Oncogene Proteins, Fusion/*genetics Proto-Oncogene Proteins c-ets/*genetics Repressor Proteins/*genetics *Translocation, Genetic
Pubmed
Web of science
Create date
25/01/2008 10:35
Last modification date
20/08/2019 13:52
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