A quantitative risk assessment for skin sensitizing plant protection products: Linking derived No-Effect levels (DNELs) with agricultural exposure models.

Details

Ressource 1Download: 2018_Sanvido_ RegulToxicolPharmacol_postprint_final.pdf (681.22 [Ko])
State: Public
Version: Author's accepted manuscript
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_46FA0A7CA6EB
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A quantitative risk assessment for skin sensitizing plant protection products: Linking derived No-Effect levels (DNELs) with agricultural exposure models.
Journal
Regulatory Toxicology and Pharmacology
Author(s)
Sanvido Olivier, Schmid Kaspar, FitzGerald Rex E., Roth Nicolas, Wilks Martin F., Bormann Peter, Hopf Nancy B.
ISSN
1096-0295 (Electronic)
ISSN-L
0273-2300
Publication state
Published
Issued date
10/2018
Peer-reviewed
Oui
Volume
98
Pages
171-183
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Chemical skin sensitizers produce allergic contact dermatitis, which is one of the most frequent occupational diseases associated with chemical exposures. Skin exposure is the major route of exposure when using plant protection products (PPPs). Therefore, skin sensitization is an important factor to be addressed during the regulatory risk assessment of PPPs. The main regulatory decision criterion considered when performing risk assessment for skin sensitizers is the dose applied. The equally important criteria "potency of the substance" is insufficiently considered by two potency categories as potency may vary up to five orders of magnitude. "Frequency of exposure" to the skin sensitizer is not considered at all. Consequently, an improved risk assessment methodology is essential to adequately assess health risks from skin sensitizers, especially for agricultural operators using PPPs. A quantitative risk assessment (QRA) approach for addressing PPPs sensitizing potential is proposed here. This QRA combines a methodology to derive a substance-specific threshold for skin sensitizers, a Derived No-Effect Level (DNEL), and an agricultural exposure model used for assessing chronic health risks of PPPs. The proposed QRA for skin sensitizing PPPs is a clear improvement over current risk assessment to ensure the safe use of skin sensitizers in an occupational context.
Keywords
Agriculture, Allergens/toxicity, Dermatitis, Allergic Contact/prevention & control, Haptens/toxicity, Models, Theoretical, No-Observed-Adverse-Effect Level, Occupational Exposure/adverse effects, Plant Diseases/prevention & control, Protective Agents/toxicity, Risk Assessment, Agricultural operator exposure model, Allergic contact dermatitis, Chemical skin sensitizers, Derived No-Effect level (DNEL), Plant protection products, Quantitative risk assessment
Pubmed
Web of science
Create date
22/08/2018 8:55
Last modification date
20/08/2019 14:52
Usage data