(106)Ruthenium brachytherapy for retinoblastoma.

Details

Serval ID
serval:BIB_46C5C89FFAD4
Type
Article: article from journal or magazin.
Collection
Publications
Title
(106)Ruthenium brachytherapy for retinoblastoma.
Journal
International Journal of Radiation Oncology, Biology, Physics
Author(s)
Abouzeid H., Moeckli R., Gaillard M.C., Beck-Popovic M., Pica A., Zografos L., Balmer A., Pampallona S., Munier F.L.
ISSN
0360-3016
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
71
Number
3
Pages
821-8
Language
english
Notes
Publication types: Journal Article - Publication Status: ppublish
Abstract
PURPOSE: To evaluate the efficacy of (106)Ru plaque brachytherapy for the treatment of retinoblastoma. METHODS AND MATERIALS: We reviewed a retrospective, noncomparative case series of 39 children with retinoblastoma treated with (106)Ru plaques at the Jules-Gonin Eye Hospital between October 1992 and July 2006, with 12 months of follow-up. RESULTS: A total of 63 tumors were treated with (106)Ru brachytherapy in 41 eyes. The median patient age was 27 months. (106)Ru brachytherapy was the first-line treatment for 3 tumors (4.8%), second-line treatment for 13 (20.6%), and salvage treatment for 47 tumors (74.6%) resistant to other treatment modalities. Overall tumor control was achieved in 73% at 1 year. Tumor recurrence at 12 months was observed in 2 (12.5%) of 16 tumors for which (106)Ru brachytherapy was used as the first- or second-line treatment and in 15 (31.9%) of 47 tumors for which (106)Ru brachytherapy was used as salvage treatment. Eye retention was achieved in 76% of cases (31 of 41 eyes). Univariate and multivariate analyses revealed no statistically significant risk factors for tumor recurrence. Radiation complications included retinal detachment in 7 (17.1%), proliferative retinopathy in 1 (2.4%), and subcapsular cataract in 4 (9.7%) of 41 eyes. CONCLUSION: (106)Ru brachytherapy is an effective treatment for retinoblastoma, with few secondary complications. Local vitreous seeding can be successfully treated with (106)Ru brachytherapy.
Keywords
Adolescent, Adult, Aged, Aged, 80 and over, Brachytherapy/methods, Child, Female, Humans, Male, Middle Aged, Retinal Neoplasms/radiotherapy, Retinoblastoma/radiotherapy, Retrospective Studies, Ruthenium Radioisotopes/therapeutic use, Treatment Outcome
Pubmed
Web of science
Create date
20/03/2008 10:34
Last modification date
20/08/2019 14:52
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