Inequity in access to personalized medicine in France: Evidences from analysis of geo variations in the access to molecular profiling among advanced non-small-cell lung cancer patients: Results from the IFCT Biomarkers France Study

Details

Ressource 1Download: document.pdf (1097.32 [Ko])
State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_46B10F05796C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Inequity in access to personalized medicine in France: Evidences from analysis of geo variations in the access to molecular profiling among advanced non-small-cell lung cancer patients: Results from the IFCT Biomarkers France Study
Journal
PLOS ONE
Author(s)
Kembou Nzale Samuel, Weeks William B., Ouafik L'Houcine, Rouquette Isabelle, Beau-Faller Michèle, Lemoine Antoinette, Bringuier Pierre-Paul, Le Coroller Soriano Anne-Gaëlle, Barlesi Fabrice, Ventelou Bruno
ISSN
1932-6203
Publication state
Published
Issued date
01/07/2020
Peer-reviewed
Oui
Editor
d'Onofrio Alberto
Volume
15
Number
7
Pages
e0234387
Language
english
Abstract
In this article, we studied geographic variation in the use of personalized genetic testing for advanced non-small cell lung cancer (NSCLC) and we evaluated the relationship between genetic testing rates and local socioeconomic and ecological variables. We used data on all advanced NSCLC patients who had a genetic test between April 2012 and April 2013 in France in the frame of the IFCT Biomarqueurs-France study (n = 15814). We computed four established measures of geographic variation of the sex-adjusted rates of genetic testing utilization at the “départment” (the French territory is divided into 94 administrative units called ‘départements’) level. We also performed a spatial regression model to determine the relationship between département-level sex-adjusted rates of genetic testing utilization and economic and ecological variables. Our results are the following: (i) Overall, 46.87% lung cancer admission patients obtained genetic testing for NSCLC; département-level utilization rates varied over 3.2-fold. Measures of geographic variation indicated a relatively high degree of geographic variation. (ii) there was a statistically significant relationship between genetic testing rates and per capita supply of general practitioners, radiotherapists and surgeons (negative correlation for the latter); lower genetic testing rates were also associated with higher local poverty rates. French policymakers should pursue effort toward deprived areas to obtain equal access to personalized medicine for advanced NSCLC patients.
Keywords
Multidisciplinary
Pubmed
Web of science
Open Access
Yes
Create date
20/10/2020 16:19
Last modification date
18/11/2021 7:09
Usage data