Prognostic Evaluations Tailored to Specific Gastric Neuroendocrine Neoplasms: Analysis Of 200 Cases with Extended Follow-Up.

Details

Serval ID
serval:BIB_46AD0B4B4A81
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Prognostic Evaluations Tailored to Specific Gastric Neuroendocrine Neoplasms: Analysis Of 200 Cases with Extended Follow-Up.
Journal
Neuroendocrinology
Author(s)
Vanoli A., La Rosa S., Miceli E., Klersy C., Maragliano R., Capuano F., Persichella A., Martino M., Inzani F., Luinetti O., Di Sabatino A., Sessa F., Paulli M., Corazza G.R., Rindi G., Bordi C., Capella C., Solcia E.
ISSN
1423-0194 (Electronic)
ISSN-L
0028-3835
Publication state
Published
Issued date
2018
Peer-reviewed
Oui
Volume
107
Number
2
Pages
114-126
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Gastric neuroendocrine neoplasms (NENs) are very heterogeneous, ranging from mostly indolent, atrophic gastritis-associated, type I neuroendocrine tumors (NETs), through highly malignant, poorly differentiated neuroendocrine carcinomas (pdNECs), to sporadic type III NETs with intermediate prognosis, and various rare tumor types. Histologic differentiation, proliferative grade, size, level of gastric wall invasion, and local or distant metastases are used as prognostic markers. However, their value remains to be tailored to specific gastric NENs.
Series of type I NETs (n = 123 cases), type III NETs (n = 34 cases), and pdNECs (n = 43 cases) were retrospectively collected from four pathology centers specializing in endocrine pathology. All cases were characterized clinically and histopathologically. During follow-up (median 93 months) data were recorded to assess disease-specific patient survival.
Type I NETs, type III NETs, and pdNECs differed markedly in terms of tumor size, grade, invasive and metastatic power, as well as patient outcome. Size was used to stratify type I NETs into subgroups with significantly different invasive and metastatic behavior. All 70 type I NETs < 0.5 cm (micro-NETs) were uneventful. Ki67-based grading proved efficient for the prognostic stratification of type III NETs; however, grade 2 (G2) was not associated with tumor behavior in type I NETs. Although G3 NETs (2 type I and 9 type III) had a very poor prognosis, it was found that patient survival was longer with type III G3 NETs compared to pdNECs.
Given the marked, tumor type-related behavior differences, evaluation of gastric NEN prognostic parameters should be tailored to the type of neoplastic disease.
Keywords
Adult, Aged, Disease-Free Survival, Female, Follow-Up Studies, Humans, Kaplan-Meier Estimate, Longitudinal Studies, Male, Middle Aged, Neuroendocrine Tumors/classification, Neuroendocrine Tumors/mortality, Neuroendocrine Tumors/pathology, Prognosis, Retrospective Studies, Stomach Neoplasms/classification, Stomach Neoplasms/mortality, Stomach Neoplasms/pathology, Gastric neuroendocrine neoplasms, Grading, Invasive behavior, Size, Stage
Pubmed
Web of science
Create date
14/06/2018 16:11
Last modification date
20/08/2019 13:52
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