Dexamethasone-induced insulin resistance shows no gender difference in healthy humans

Details

Serval ID
serval:BIB_46A4764A12B8
Type
Article: article from journal or magazin.
Collection
Publications
Title
Dexamethasone-induced insulin resistance shows no gender difference in healthy humans
Journal
Diabetes and Metabolism
Author(s)
Binnert  C., Ruchat  S., Nicod  N., Tappy  L.
ISSN
1262-3636 (Print)
Publication state
Published
Issued date
09/2004
Volume
30
Number
4
Pages
321-6
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Sep
Abstract
OBJECTIVE: Recent reports suggest that lipid-induced insulin resistance is more pronounced in men than in women. Whether such gender difference exists for other factors known to induce insulin resistance in healthy individuals remains unknown. We therefore assessed whether glucocorticoid-induced insulin resistance differs in men and women. METHODS: The insulin sensitivity and insulin secretion of 8 women and 7 men, all non obese and healthy, were evaluated with or without administration of dexamethasone (2 mg/day during 2 days) by means of a two-step hyperglycemic clamp. RESULTS: Dexamethasone decreased insulin sensitivity to the same extent in men and women. The relative increases in insulin concentration observed after dexamethasone in the basal state, during the first phase of insulin release and at the two steps of hyperglycemia were similar in men and women. The hyperinsulinemia thus attained allowed to fully compensate for insulin resistance in both genders. CONCLUSIONS: The effects of glucocorticoids on insulin sensitivity and insulin secretion show no gender difference in healthy humans.
Keywords
Adult Blood Glucose/drug effects/metabolism Dexamethasone/*pharmacology Fatty Acids, Nonesterified/blood Female Glucose Clamp Technique Humans Insulin/blood/*secretion Insulin Resistance/*physiology Male Reference Values Sex Characteristics
Pubmed
Web of science
Create date
24/01/2008 14:36
Last modification date
20/08/2019 14:52
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