Histological behavior of glutaraldehyde cross-linked bovine collagen injected into the human bladder for the treatment of vesicoureteral reflux

Details

Serval ID
serval:BIB_46962B6F12B5
Type
Article: article from journal or magazin.
Collection
Publications
Title
Histological behavior of glutaraldehyde cross-linked bovine collagen injected into the human bladder for the treatment of vesicoureteral reflux
Journal
Journal of Urology
Author(s)
Frey  P., Lutz  N., Berger  D., Herzog  B.
ISSN
0022-5347
Publication state
Published
Issued date
08/1994
Peer-reviewed
Oui
Volume
152
Number
2 Pt 2
Pages
632-5
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Aug
Abstract
Endoscopic subureteral collagen injection has become an accepted means for the treatment of vesicoureteral reflux in children. The aim of this study was to evaluate the histological behavior of glutaraldehyde cross-linked bovine collagen implants. The specimens were harvested from 29 patients who underwent reimplant surgery 2 to 30 months (mean 9.5) after unsuccessful subureteral injection therapy. In addition to routine hematoxylin and eosin staining, a new staining method (solophenyl red 3BL) able to demonstrate selectively neoformation of types I and III human collagen, was applied. Invasion of host fibroblasts into the bovine implant and the formation of endogenous types I and III collagen were demonstrated in all 29 cases. Adverse histological reactions were rare and, if present, they were predominantly of an inflammatory nature.
Keywords
Biocompatible Materials Calcinosis/etiology/pathology Collagen/administration & dosage/adverse effects/metabolism/*therapeutic use Cross-Linking Reagents Endoscopy Fibroblasts/pathology Foreign-Body Reaction/etiology/pathology Humans Inflammation/etiology/pathology Injections Prostheses and Implants Urinary Bladder Vesico-Ureteral Reflux/metabolism/pathology/*therapy
Pubmed
Web of science
Create date
28/02/2008 11:25
Last modification date
20/08/2019 14:52
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