Presence of multiple "Helicobacter heilmannii" strains in an individual suffering from ulcers and in his two cats

Details

Serval ID
serval:BIB_4669CB8F8BC7
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Presence of multiple "Helicobacter heilmannii" strains in an individual suffering from ulcers and in his two cats
Journal
Journal of Clinical Microbiology
Author(s)
Dieterich  C., Wiesel  P., Neiger  R., Blum  A., Corthesy-Theulaz  I.
ISSN
0095-1137 (Print)
Publication state
Published
Issued date
05/1998
Volume
36
Number
5
Pages
1366-70
Notes
Case Reports
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: May
Abstract
Circumstantial evidence suggests that "Helicobacter heilmannii" infection is an example of zoonosis. The presence of "H. heilmannii" strains in a human subject with acute gastric erosions, in his two cats, and in two unrelated cats was analyzed, and the genetic relatedness of the human and feline strains was assessed. A 580-bp, PCR-amplified sequence of "H. heilmannii" urease B gene (ureB) obtained from biopsies from the human subject and his two cats was restricted with AluI and cloned for sequencing. Analysis of the restriction fragment length polymorphism of the ureB-amplified product suggested the presence of different individual "H. heilmannii" strains in the cats and of three distinct strains in the human subject. One of the "H. heilmannii" ureB sequences amplified from the human subject's biopsies was identical to that derived from one of his cats. The degree of similarity between the other "H. heilmannii" human and feline nucleotide sequences was higher than 97%. Most of the base substitutions were conservative. We conclude that human and animal "H. heilmannii" strains are closely related and that humans can be infected by more than one "H. heilmannii" strain, as has been observed for Helicobacter pylori.
Keywords
Adult Animals Base Sequence Cats/*microbiology Helicobacter/*classification/enzymology/isolation & purification Helicobacter Infections/enzymology/*microbiology/veterinary Humans Male Molecular Sequence Data Polymorphism, Restriction Fragment Length Repetitive Sequences, Nucleic Acid Restriction Mapping Sequence Alignment Sequence Homology, Nucleic Acid Stomach Ulcer/*microbiology Urease/analysis Zoonoses/*microbiology
Pubmed
Web of science
Create date
25/01/2008 17:12
Last modification date
20/08/2019 14:51
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