Positron emission tomography for the early postsurgical evaluation of pediatric brain tumors.
Details
Serval ID
serval:BIB_4639F3EF49BD
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Positron emission tomography for the early postsurgical evaluation of pediatric brain tumors.
Journal
Child's Nervous System
ISSN
0256-7040 (Print)
ISSN-L
0256-7040
Publication state
Published
Issued date
2005
Peer-reviewed
Oui
Volume
21
Number
4
Pages
294-300
Language
english
Notes
Publication types: Comparative Study ; Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
OBJECT: The object was to study the value of postoperative positron emission tomography (PET) to assess the extension of brain tumor resection.
METHODS: Twenty children operated on for total resection of a glial tumor (18 low-grade, 2 anaplastic) presented a signal on postoperative magnetic resonance (MR) images raising the question of a possible tumor residue. PET was performed early ((18)F-Fluoro-deoxyglucose in 1, (11)C-methionine in 16, both in 3) to further characterize the nature of the abnormal MR signal in order to consider second-look surgery. An increased tracer uptake found in 14 children led to reoperation on 11 of them, confirming the tumor histologically. No (11)C-methionine uptake led to a conservative attitude in 6 children in whom MR imaging follow-up showed no tumor progression.
CONCLUSIONS: The early postoperative PET, especially with (11)C-methionine, appears to be a valid basis for complementary therapeutic decisions, especially second-look surgery, in glial tumors for which a radical resection is a key factor for prognosis.
METHODS: Twenty children operated on for total resection of a glial tumor (18 low-grade, 2 anaplastic) presented a signal on postoperative magnetic resonance (MR) images raising the question of a possible tumor residue. PET was performed early ((18)F-Fluoro-deoxyglucose in 1, (11)C-methionine in 16, both in 3) to further characterize the nature of the abnormal MR signal in order to consider second-look surgery. An increased tracer uptake found in 14 children led to reoperation on 11 of them, confirming the tumor histologically. No (11)C-methionine uptake led to a conservative attitude in 6 children in whom MR imaging follow-up showed no tumor progression.
CONCLUSIONS: The early postoperative PET, especially with (11)C-methionine, appears to be a valid basis for complementary therapeutic decisions, especially second-look surgery, in glial tumors for which a radical resection is a key factor for prognosis.
Keywords
Adolescent, Brain Neoplasms/pathology, Brain Neoplasms/radionuclide imaging, Child, Child, Preschool, Female, Fluorodeoxyglucose F18/diagnostic use, Fluorodeoxyglucose F18/pharmacokinetics, Humans, Image Processing, Computer-Assisted/methods, Male, Methionine/diagnostic use, Methionine/pharmacokinetics, Positron-Emission Tomography, Retrospective Studies
Pubmed
Web of science
Create date
20/01/2008 18:35
Last modification date
20/08/2019 14:51