Traitements aggravant une infection par le COVID-19 : vraiment ? [Drugs that aggravate the course of COVID-19 : really ?]

Details

Serval ID
serval:BIB_460B9B6D3CDA
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Traitements aggravant une infection par le COVID-19 : vraiment ? [Drugs that aggravate the course of COVID-19 : really ?]
Journal
Revue medicale suisse
Author(s)
Rothuizen L.E., Livio F., Buclin T.
ISSN
1660-9379 (Print)
ISSN-L
1660-9379
Publication state
Published
Issued date
29/04/2020
Peer-reviewed
Oui
Volume
16
Number
N° 691-2
Pages
852-854
Language
french
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
The safety of NSAIDs, corticosteroids and renin-angiotensin inhibitors in COVID-19 is challenged. NSAIDs may interfere with the defense process against viral infection and are best avoided. Systemic corticosteroids have not shown benefit in viral infection, including other coronavirus; thus they should be avoided, unless prescribed for another indication. The benefit-risk ratio is however clearly in favor of continuing inhaled corticosteroids in patients with asthma or COPD. ACE inhibitors and sartans upregulate the expression of angiotensin-converting enzyme 2 (ACE2), the pulmonary receptor for SARS-CoV-2. Any possible clinical impact of these treatments on COVID-19 infection remains to be clarified; in the meantime, they should be continued.
Keywords
Adrenal Cortex Hormones/administration & dosage, Adrenal Cortex Hormones/adverse effects, Angiotensin-Converting Enzyme Inhibitors/administration & dosage, Anti-Inflammatory Agents, Non-Steroidal/administration & dosage, Anti-Inflammatory Agents, Non-Steroidal/adverse effects, Betacoronavirus, Coronavirus Infections/complications, Coronavirus Infections/epidemiology, Humans, Pandemics, Pneumonia, Viral/complications, Pneumonia, Viral/epidemiology
Pubmed
Create date
02/05/2020 14:50
Last modification date
22/07/2020 6:26
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