Effects of chemical & biological warfare agent decontaminants on trace survival: Impact on DNA profiling from blood and saliva

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_4600851DC3AC
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effects of chemical & biological warfare agent decontaminants on trace survival: Impact on DNA profiling from blood and saliva
Journal
Forensic Science International
Author(s)
Radgen-Morvant Isabelle, Curty Christophe, Kummer Natalie, Delémont Olivier
ISSN
0379-0738
Publication state
Published
Issued date
11/2024
Peer-reviewed
Oui
Volume
364
Pages
112206
Language
english
Abstract
Forensic investigations following incidents involving chemical or biological agents present considerable challenges. Understanding the possibilities and limitations can aid in determining the most suitable procedures and enhancing the recovery of useful traces in these complex situations. This work complements previously published results on the effects of decontaminants on fingermarks deposited on glass. Identifying the perpetrators can be crucial, and DNA analysis remains a cornerstone in this regard. In this study, we investigated the ability to obtain usable DNA profiles from blood and saliva (pure and diluted) exposed to 16 different decontamination methods. Both DNA quantitation and DNA profiling were considered to assess the outcomes. The results revealed considerable variability but indicated that biological agents' decontaminants hindered DNA profiling post-decontamination to a greater extent than decontaminants aimed for chemical agents. Chlorine-based decontaminants also globally had a deleterious impact on DNA profiling. Powder decontaminants such as Fast-Act, CHpowder, and the liquid decontaminants GDS2000 did not affect DNA profiling.
Keywords
Forensic, DNA, CBRN, Decontaminants, STR, profiling, Degradation index
Open Access
Yes
Create date
12/09/2024 18:47
Last modification date
13/09/2024 16:24
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