A conjugation-like mechanism for prespore chromosome partitioning during sporulation in Bacillus subtilis

Details

Serval ID
serval:BIB_45E82F174656
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A conjugation-like mechanism for prespore chromosome partitioning during sporulation in Bacillus subtilis
Journal
Genes and Development
Author(s)
Wu  L. J., Lewis  P. J., Allmansberger  R., Hauser  P. M., Errington  J.
ISSN
0890-9369 (Print)
Publication state
Published
Issued date
06/1995
Volume
9
Number
11
Pages
1316-26
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jun 1
Abstract
Spore formation in Bacillus subtilis begins with an asymmetric cell division that superficially resembles the division of vegetative cells. Mutations in the spoIIIE gene of B. subtilis partially block partitioning of one chromosome into the smaller (prespore) compartment of the sporulating cell. Point mutations that specifically block prespore chromosome partitioning affect a carboxy-terminal domain of SpoIIIE that shows significant sequence similarity to the DNA transfer (Tra) proteins of several conjugative plasmids of Streptomyces. In wild-type sporulating cells, the prespore chromosome passes through an intermediate stage resembling the state in which spoIIIE mutant cells are blocked. The prespore chromosome is then transferred progressively through the newly formed spore septum. We propose that translocation of the prespore chromosome occurs by a mechanism that is functionally related to the conjugative transfer of plasmid DNA.
Keywords
Bacillus subtilis/*physiology Base Sequence Chromosomes/genetics Conjugation, Genetic Molecular Sequence Data Mutation Spores, Bacterial/*physiology
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 14:30
Last modification date
20/08/2019 13:51
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