Leptin and psychiatric illnesses: does leptin play a role in antipsychotic-induced weight gain?

Details

Serval ID
serval:BIB_45C4E5089AD1
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Leptin and psychiatric illnesses: does leptin play a role in antipsychotic-induced weight gain?
Journal
Lipids in health and disease
Author(s)
Endomba F.T., Tankeu A.T., Nkeck J.R., Tochie J.N.
ISSN
1476-511X (Electronic)
ISSN-L
1476-511X
Publication state
Published
Issued date
07/02/2020
Peer-reviewed
Oui
Volume
19
Number
1
Pages
22
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
Antipsychotic-induced weight gain is the most prevalent somatic adverse event occurring in patients treated by antipsychotics, especially atypical antipsychotics. It is of particular interest because of its repercussion on cardiovascular morbidity and mortality especially now that the use of second-generation antipsychotics has been extended to other mental health illnesses such as bipolar disorders and major depressive disorder. The mechanism underlying antipsychotics-induced weight gain is still poorly understood despite a significant amount of work on the topic. Recently, there has been an on-going debate of tremendous research interest on the relationship between antipsychotic-induced weight gain and body weight regulatory hormones such as leptin. Given that, researchers have brought to light the question of leptin's role in antipsychotic-induced weight gain. Here we summarize and discuss the existing evidence on the link between leptin and weight gain related to antipsychotic drugs, especially atypical antipsychotics.
Keywords
Antipsychotic drugs, Antipsychotic-induced weight gain, Leptin, Mental health disorders, Second-generation antipsychotics
Pubmed
Open Access
Yes
Create date
17/02/2020 16:39
Last modification date
15/07/2020 6:26
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