Human TH9 cells are skin-tropic and have autocrine and paracrine proinflammatory capacity.

Details

Serval ID
serval:BIB_45B0DC2B96F2
Type
Article: article from journal or magazin.
Collection
Publications
Title
Human TH9 cells are skin-tropic and have autocrine and paracrine proinflammatory capacity.
Journal
Science translational medicine
Author(s)
Schlapbach C., Gehad A., Yang C., Watanabe R., Guenova E., Teague J.E., Campbell L., Yawalkar N., Kupper T.S., Clark R.A.
ISSN
1946-6242 (Electronic)
ISSN-L
1946-6234
Publication state
Published
Issued date
15/01/2014
Peer-reviewed
Oui
Volume
6
Number
219
Pages
219ra8
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
T helper type 9 (TH9) cells can mediate tumor immunity and participate in autoimmune and allergic inflammation in mice, but little is known about the TH9 cells that develop in vivo in humans. We isolated T cells from human blood and tissues and found that most memory TH9 cells were skin-tropic or skin-resident. Human TH9 cells coexpressed tumor necrosis factor-α and granzyme B and lacked coproduction of TH1/TH2/TH17 cytokines, and many were specific for Candida albicans. Interleukin-9 (IL-9) production was transient and preceded the up-regulation of other inflammatory cytokines. Blocking studies demonstrated that IL-9 was required for maximal production of interferon-γ, IL-9, IL-13, and IL-17 by skin-tropic T cells. IL-9-producing T cells were increased in the skin lesions of psoriasis, suggesting that these cells may contribute to human inflammatory skin disease. Our results indicate that human TH9 cells are a discrete T cell subset, many are tropic for the skin, and although they may function normally to protect against extracellular pathogens, aberrant activation of these cells may contribute to inflammatory diseases of the skin.
Keywords
Animals, Autocrine Communication/drug effects, Autocrine Communication/immunology, Candida albicans/drug effects, Candida albicans/physiology, Dermatitis, Atopic/immunology, Dermatitis, Atopic/pathology, Humans, Inflammation/immunology, Inflammation/pathology, Interleukin-2/pharmacology, Interleukin-9/metabolism, Lymphocyte Activation/drug effects, Lymphocyte Activation/immunology, Mice, Paracrine Communication/drug effects, Paracrine Communication/immunology, Psoriasis/immunology, Psoriasis/pathology, Skin/drug effects, Skin/immunology, Skin/pathology, T-Lymphocytes, Helper-Inducer/drug effects, T-Lymphocytes, Helper-Inducer/immunology, T-Lymphocytes, Helper-Inducer/microbiology, Transforming Growth Factor beta/pharmacology
Pubmed
Web of science
Create date
27/08/2020 14:59
Last modification date
02/09/2020 6:26
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