Correlation of lung abnormalities on high-resolution CT with clinical graft-versus-host disease after allogeneic versus autologous bone marrow transplantation in children.

Details

Serval ID
serval:BIB_45A7C29E1BEA
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Correlation of lung abnormalities on high-resolution CT with clinical graft-versus-host disease after allogeneic versus autologous bone marrow transplantation in children.
Journal
Pediatric radiology
Author(s)
Merlini L., Borzani I.M., Anooshiravani M., Rochat I., Ozsahin A.H., Hanquinet S.
ISSN
0301-0449 (Print)
ISSN-L
0301-0449
Publication state
Published
Issued date
11/2008
Peer-reviewed
Oui
Volume
38
Number
11
Pages
1201-1209
Language
english
Notes
Publication types: Comparative Study ; Journal Article
Publication Status: ppublish
Abstract
Late-onset noninfectious pulmonary complications (LONIPCs) are life-threatening complications of bone marrow transplantation (BMT). Several pathological patterns are described in the literature with different prognoses, and with different relationships to graft-versus-host disease (GVHD). The role of high-resolution CT (HRCT) is not yet well established.
To illustrate different patterns of LONIPCs on HRCT in allogeneic versus autologous BMT in order to investigate the correlation with chronic GVHD (cGVHD).
A total of 67 HRCT scans were performed in 24 patients with noninfectious pulmonary disease at least 3 months after BMT (16 allogeneic, 8 autologous). Abnormality patterns and extension on HRCT images were correlated with the clinical outcome and with the severity of cGVHD.
Of 24 patients, 9 showed LONIPCs (1 autologous, 8 allogeneic). There was a significant association between abnormalities on HRCT and severe cGVHD (P = 0.038), with no specific pattern. Prognosis seemed to be related to the severity of cGVHD and not to the extent of abnormalities on HRCT.
The significant association between abnormalities on HRCT and severe GVHD suggests that LONIPCs can be a pulmonary manifestation of the disease. HRCT is a useful tool when combined with clinical data.
Keywords
Adolescent, Bone Marrow Transplantation, Child, Child, Preschool, Female, Graft vs Host Disease/diagnostic imaging, Humans, Infant, Longitudinal Studies, Lung Diseases/diagnostic imaging, Male, Postoperative Complications/diagnostic imaging, Tomography, X-Ray Computed/methods, Transplantation, Autologous, Transplantation, Homologous
Pubmed
Web of science
Create date
04/03/2018 16:47
Last modification date
28/08/2020 5:26
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