Lamotrigine can be beneficial in patients with Dravet syndrome.

Details

Serval ID
serval:BIB_4571A587B978
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Title
Lamotrigine can be beneficial in patients with Dravet syndrome.
Journal
Developmental Medicine and Child Neurology
Author(s)
Dalic L., Mullen S.A., Roulet Perez E., Scheffer I.
ISSN
1469-8749 (Electronic)
ISSN-L
0012-1622
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
57
Number
2
Pages
200-202
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
Dravet syndrome, a severe infantile epilepsy syndrome, is typically resistant to anti-epileptic drugs (AED). Lamotrigine (LTG), an AED that is effective for both focal and generalized seizures, has been reported to aggravate seizures in Dravet syndrome. Therefore, LTG is usually avoided in Dravet syndrome. We describe two adults and a child with Dravet syndrome in whom LTG resulted in decreased seizure duration and frequency. This benefit was highlighted in each patient when LTG was withdrawn after 6 to 15 years, and resulted in an increased frequency of convulsive seizures together with longer seizure duration. A 25-year-old male required hospital admission for frequent seizures for the first time in 7 years, 6 weeks after ceasing LTG. Reintroduction of LTG improved seizure control, suggesting that in some patients with Dravet syndrome, LTG may be beneficial.
Pubmed
Web of science
Open Access
Yes
Create date
07/02/2015 13:56
Last modification date
20/08/2019 13:50
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