Cross talk between intracellular pathogens and cell death.

Details

Serval ID
serval:BIB_456F4BB4C5ED
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Cross talk between intracellular pathogens and cell death.
Journal
Immunological reviews
Author(s)
Demarco B., Chen K.W., Broz P.
ISSN
1600-065X (Electronic)
ISSN-L
0105-2896
Publication state
Published
Issued date
22/06/2020
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: aheadofprint
Abstract
Infections with bacterial pathogens often results in the initiation of programmed cell death as part of the host innate immune defense, or as a bacterial virulence strategy. Induction of host cell death is controlled by an elaborate network of innate immune and cell death signaling pathways and manifests in different morphologically and functionally distinct forms of death, such as apoptosis, necroptosis, NETosis and pyroptosis. The mechanism by which host cell death restricts bacterial replication is highly cell-type and context depended, but its physiological importance is highlighted the diversity of strategies bacterial pathogens use to avoid induction of cell death or to block cell death signaling pathways. In this review, we discuss the latest insights into how bacterial pathogens elicit and manipulate cell death signaling, how different forms of cell death kill or restrict bacteria and how cell death and innate immune pathway cross talk to guard against pathogen-induced inhibition of host cell death.
Keywords
apoptosis, infection, innate immunity, necroptosis, programmed cell death, pyroptosis
Pubmed
Web of science
Create date
24/06/2020 17:54
Last modification date
24/07/2020 6:21
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