2016 updated EULAR evidence-based recommendations for the management of gout.

Details

Serval ID
serval:BIB_456CA3C190A7
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
2016 updated EULAR evidence-based recommendations for the management of gout.
Journal
Annals of the rheumatic diseases
Author(s)
Richette P., Doherty M., Pascual E., Barskova V., Becce F., Castañeda-Sanabria J., Coyfish M., Guillo S., Jansen T.L., Janssens H., Lioté F., Mallen C., Nuki G., Perez-Ruiz F., Pimentao J., Punzi L., Pywell T., So A., Tausche A.K., Uhlig T., Zavada J., Zhang W., Tubach F., Bardin T.
ISSN
1468-2060 (Electronic)
ISSN-L
0003-4967
Publication state
Published
Issued date
01/2017
Peer-reviewed
Oui
Volume
76
Number
1
Pages
29-42
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
New drugs and new evidence concerning the use of established treatments have become available since the publication of the first European League Against Rheumatism (EULAR) recommendations for the management of gout, in 2006. This situation has prompted a systematic review and update of the 2006 recommendations.
The EULAR task force consisted of 15 rheumatologists, 1 radiologist, 2 general practitioners, 1 research fellow, 2 patients and 3 experts in epidemiology/methodology from 12 European countries. A systematic review of the literature concerning all aspects of gout treatments was performed. Subsequently, recommendations were formulated by use of a Delphi consensus approach.
Three overarching principles and 11 key recommendations were generated. For the treatment of flare, colchicine, non-steroidal anti-inflammatory drugs (NSAIDs), oral or intra-articular steroids or a combination are recommended. In patients with frequent flare and contraindications to colchicine, NSAIDs and corticosteroids, an interleukin-1 blocker should be considered. In addition to education and a non-pharmacological management approach, urate-lowering therapy (ULT) should be considered from the first presentation of the disease, and serum uric acid (SUA) levels should be maintained at<6 mg/dL (360 µmol/L) and <5 mg/dL (300 µmol/L) in those with severe gout. Allopurinol is recommended as first-line ULT and its dosage should be adjusted according to renal function. If the SUA target cannot be achieved with allopurinol, then febuxostat, a uricosuric or combining a xanthine oxidase inhibitor with a uricosuric should be considered. For patients with refractory gout, pegloticase is recommended.
These recommendations aim to inform physicians and patients about the non-pharmacological and pharmacological treatments for gout and to provide the best strategies to achieve the predefined urate target to cure the disease.

Pubmed
Open Access
Yes
Create date
12/12/2016 17:08
Last modification date
20/08/2019 14:50
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