Surgical injury induces local and distant adipose tissue browning.

Details

Serval ID
serval:BIB_456663FE0046
Type
Article: article from journal or magazin.
Collection
Publications
Title
Surgical injury induces local and distant adipose tissue browning.
Journal
Adipocyte
Author(s)
Longchamp A., Tao M., Bartelt A., Ding K., Lynch L., Hine C., Corpataux J.M., Kristal B.S., Mitchell J.R., Ozaki C.K.
ISSN
2162-397X (Electronic)
ISSN-L
2162-3945
Publication state
Published
Issued date
2016
Peer-reviewed
Oui
Volume
5
Number
2
Pages
163-174
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
The adipose organ, which comprises brown, white and beige adipocytes, possesses remarkable plasticity in response to feeding and cold exposure. The development of beige adipocytes in white adipose tissue (WAT), a process called browning, represents a promising route to treat metabolic disorders. While surgical procedures constantly traumatize adipose tissue, its impact on adipocyte phenotype remains to be established. Herein, we studied the effect of trauma on adipocyte phenotype one day after sham, incision control, or surgical injury to the left inguinal adipose compartment. Caloric restriction was used to control for surgery-associated body temperature changes and weight loss. We characterized the trauma-induced cellular and molecular changes in subcutaneous, visceral, interscapular, and perivascular adipose tissue using histology, immunohistochemistry, gene expression, and flow cytometry analysis. After one day, surgical trauma stimulated adipose tissue browning at the site of injury and, importantly, in the contralateral inguinal depot. Browning was not present after incision only, and was largely independent of surgery-associated body temperature and weight loss. Adipose trauma rapidly recruited monocytes to the injured site and promoted alternatively activated macrophages. Conversely, PDGF receptor-positive beige progenitors were reduced. In this study, we identify adipose trauma as an unexpected driver of selected local and remote adipose tissue browning, holding important implications for the biologic response to surgical injury.
Keywords
adipose, beige adipose, browning, dietary restriction, surgery, trauma
Pubmed
Web of science
Open Access
Yes
Funding(s)
Swiss National Science Foundation / Careers / P1LAP3_158895
Create date
07/03/2021 13:54
Last modification date
08/03/2021 7:26
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