Oesophageal atresia: prevalence, prenatal diagnosis and associated anomalies in 23 European regions.
Details
Serval ID
serval:BIB_452998EFD430
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Oesophageal atresia: prevalence, prenatal diagnosis and associated anomalies in 23 European regions.
Journal
Archives of Disease in Childhood
Working group(s)
EUROCAT Working group
Contributor(s)
Haeusler M., Nelen V., Barisic I., Randrianaivo-Ranjatoelina H., Doray B., Wiesel A., Rissmann A., O'Mahony M., McDonnell B., Mullaney C., Neville A., Bianchi F., Gatt M., Bakker M., Salvador J., Addor MC., Associée M., Wertelecki W., Draper E., Boyd P., Rankin J., Tucker D., Wellesley D.
ISSN
1468-2044 (Electronic)
ISSN-L
0003-9888
Publication state
Published
Issued date
2012
Volume
97
Number
3
Pages
227-232
Language
english
Notes
Publication types: Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
OBJECTIVE: To describe prevalence, prenatal diagnosis and epidemiological data on oesophageal atresia from 23 well-defined European regions and compare the prevalence between these regions.
DESIGN: Population-based study using data from a large European database for surveillance of congenital anomalies (EUROCAT) for two decades (1987-2006).
SETTINGS: Twenty-three participating registries based on multiple sources of information including information about live births, fetal deaths with gestational age ≥20 weeks and terminations of pregnancy.
PATIENTS: 1222 cases of oesophageal atresia in a population of 5 019 804 births.
RESULTS: The overall prevalence was 2.43 cases per 10 000 births (95% CI 2.30 to 2.57). There were regional differences in prevalence ranging from 1.27 to 4.55. Prenatal detection rates varied by registry from >50% of cases to <10% of cases. A total of 546 cases (44.7%) had an isolated oesophageal anomaly, 386 (31.6%) were multiple malformed and 290 (23.7%) had an association or a syndrome. There were 1084 live born cases (88.7%), 43 cases were fetal deaths and 95 cases were terminations of pregnancy. One-week survival for live births was 86.9% and 99.2% if the gestational age was ≥38 weeks and isolated oesophageal atresia was present. Males accounted for 57.3% of all cases and 38.5% of live born cases were born with gestational age <37 weeks.
CONCLUSION: There were regional differences in prevalence of oesophageal atresia in Europe. Half of all cases had associated anomalies. Prenatal detection rate increased from 26% to 36.5% over the two decades. Survival in infants with isolated oesophageal atresia born at term is high.
DESIGN: Population-based study using data from a large European database for surveillance of congenital anomalies (EUROCAT) for two decades (1987-2006).
SETTINGS: Twenty-three participating registries based on multiple sources of information including information about live births, fetal deaths with gestational age ≥20 weeks and terminations of pregnancy.
PATIENTS: 1222 cases of oesophageal atresia in a population of 5 019 804 births.
RESULTS: The overall prevalence was 2.43 cases per 10 000 births (95% CI 2.30 to 2.57). There were regional differences in prevalence ranging from 1.27 to 4.55. Prenatal detection rates varied by registry from >50% of cases to <10% of cases. A total of 546 cases (44.7%) had an isolated oesophageal anomaly, 386 (31.6%) were multiple malformed and 290 (23.7%) had an association or a syndrome. There were 1084 live born cases (88.7%), 43 cases were fetal deaths and 95 cases were terminations of pregnancy. One-week survival for live births was 86.9% and 99.2% if the gestational age was ≥38 weeks and isolated oesophageal atresia was present. Males accounted for 57.3% of all cases and 38.5% of live born cases were born with gestational age <37 weeks.
CONCLUSION: There were regional differences in prevalence of oesophageal atresia in Europe. Half of all cases had associated anomalies. Prenatal detection rate increased from 26% to 36.5% over the two decades. Survival in infants with isolated oesophageal atresia born at term is high.
Keywords
Abnormalities, Multiple/diagnosis, Abnormalities, Multiple/epidemiology, Abortion, Induced/utilization, Esophageal Atresia/diagnosis, Esophageal Atresia/epidemiology, Europe/epidemiology, Female, Fetal Death, Fetal Diseases/diagnosis, Gestational Age, Humans, Infant, Newborn, International Cooperation, Male, Pregnancy, Prenatal Diagnosis/utilization, Prevalence, Prognosis, Registries, Sex Distribution, Tracheoesophageal Fistula/epidemiology
Pubmed
Web of science
Create date
14/02/2013 10:25
Last modification date
20/08/2019 14:49
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