Phantom-based image quality assessment of clinical <sup>18</sup>F-FDG protocols in digital PET/CT and comparison to conventional PMT-based PET/CT.

Details

Serval ID
serval:BIB_44D4CADAB6FE
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Phantom-based image quality assessment of clinical <sup>18</sup>F-FDG protocols in digital PET/CT and comparison to conventional PMT-based PET/CT.
Journal
EJNMMI physics
Author(s)
Gnesin S., Kieffer C., Zeimpekis K., Papazyan J.P., Guignard R., Prior J.O., Verdun F.R., Lima TVM
ISSN
2197-7364 (Print)
ISSN-L
2197-7364
Publication state
Published
Issued date
06/01/2020
Peer-reviewed
Oui
Volume
7
Number
1
Pages
1
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
We assessed and compared image quality obtained with clinical <sup>18</sup> F-FDG whole-body oncologic PET protocols used in three different, state-of-the-art digital PET/CT and two conventional PMT-based PET/CT devices. Our goal was to evaluate an improved trade-off between administered activity (patient dose exposure/signal-to-noise ratio) and acquisition time (patient comfort) while preserving diagnostic information achievable with the recently introduced digital detector technology compared to previous analogue PET technology.
We performed list-mode (LM) PET acquisitions using a NEMA/IEC NU2 phantom, with activity concentrations of 5 kBq/mL and 25 kBq/mL for the background (9.5 L) and sphere inserts, respectively. For each device, reconstructions were obtained varying the image statistics (10, 30, 60, 90, 120, 180, and 300 s from LM data) and the number of iterations (range 1 to 10) in addition to the employed local clinical protocol setup. We measured for each reconstructed dataset: the quantitative cross-calibration, the image noise on the uniform background assessed by the coefficient of variation (COV), and the recovery coefficients (RCs) evaluated in the hot spheres. Additionally, we compared the characteristic time-activity-product (TAP) that is the product of scan time per bed position × mass-activity administered (in min·MBq/kg) across datasets.
Good system cross-calibration was obtained for all tested datasets with < 6% deviation from the expected value was observed. For all clinical protocol settings, image noise was compatible with clinical interpretation (COV < 15%). Digital PET showed an improved background signal-to-noise ratio as compared to conventional PMT-based PET. RCs were comparable between digital and PMT-based PET datasets. Compared to PMT-based PET, digital systems provided comparable image quality with lower TAP (from ~ 40% less and up to 70% less).
This study compared the achievable clinical image quality in three state-of-the-art digital PET/CT devices (from different vendors) as well as in two conventional PMT-based PET. Reported results show that a comparable image quality is achievable with a TAP reduction of ~ 40% in digital PET. This could lead to a significant reduction of the administered mass-activity and/or scan time with direct benefits in terms of dose exposure and patient comfort.
Keywords
Digital PET/CT, Dose reduction, Image quality, Protocol optimization
Pubmed
Open Access
Yes
Create date
10/01/2020 15:44
Last modification date
17/01/2020 7:26
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