Primary hyperparathyroidism and rickets. A case report and review of the literature

Details

Serval ID
serval:BIB_44C86530EB44
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Primary hyperparathyroidism and rickets. A case report and review of the literature
Journal
Helvetica Paediatrica Acta
Author(s)
Theintz  G. E., Sizonenko  P. C., Paunier  L.
ISSN
0018-022X (Print)
Publication state
Published
Issued date
12/1984
Volume
39
Number
5-6
Pages
509-16
Notes
Case Reports
Journal Article --- Old month value: Dec
Abstract
A case of primary hyperparathyroidism with clinical signs of rickets in a 15-year-old boy of South Morocco is presented. X-ray findings include a diffusely osteoporotic skeleton with areas of subperiostal resorption, cysts and metaphyseal rachitic changes. Hypercalcaemia, hypophosphataemia, increased alkaline phosphatase are found together with low calcidiol and high calcitriol plasma levels. The surgical removal of a chief-cell adenoma of a parathyroid gland leads to very rapid bone healing as well as normalization of blood chemistry. Reviewing the literature shows that 10 similar cases have been described. However, no correlation can be established between the occurrence of rachitic lesions and the Ca X P product. When limited calcium is available from the gut, elevated calcitriol then contributes to mobilize more mineral from bone, in conjunction with parathormone. In addition, the interaction of these 2 hormones on the renal tubule maintains a phosphate leak, creating proper conditions for the development of rachitic lesions.
Keywords
Adenoma/diagnosis Adolescent Calcifediol/blood Calcitriol/blood Humans Hyperparathyroidism/blood/*complications Male Parathyroid Neoplasms/diagnosis Rickets/*etiology/radiography
Pubmed
Web of science
Create date
25/01/2008 10:31
Last modification date
20/08/2019 13:49
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