Identification of pharmaceutical tablets by Raman spectroscopy and chemometrics

Details

Serval ID
serval:BIB_4428092B5698
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Identification of pharmaceutical tablets by Raman spectroscopy and chemometrics
Journal
Talanta
Author(s)
Roggo Y., Degardin K., Margot P.
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
81
Number
3
Pages
988-995
Language
english
Abstract
Raman spectroscopy has become an attractive tool for the analysis of pharmaceutical solid dosage forms. In the present study it is used to ensure the identity of tablets. The two main applications of this method are release of final products in quality control and detection of counterfeits. Twenty-five product families of tablets have been included in the spectral library and a non-linear classification method, the Support Vector Machines (SVMs), has been employed. Two calibrations have been developed in cascade: the first one identifies the product family while the second one specifies the formulation. A product family comprises different formulations that have the same active pharmaceutical ingredient (API) but in a different amount. Once the tablets have been classified by the SVM model, API peaks detection and correlation are applied in order to have a specific method for the identification and allow in the future to discriminate counterfeits from genuine products. This calibration strategy enables the identification of 25 product families without error and in the absence of prior information about the sample. Raman spectroscopy coupled with chemometrics is therefore a fast and accurate tool for the identification of pharmaceutical tablets.
Keywords
Raman spectroscopy, Pharmaceutical tablets, Chemometrics, SVM, Chemical identification, Counterfeits
Create date
23/02/2010 14:55
Last modification date
20/08/2019 14:48
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