Long-term Outcome after Liver Resection for Hepatocellular Carcinoma Larger than 10 cm.

Details

Ressource 1Download: serval:BIB_43F3EEE894DD.P001 (238.78 [Ko])
State: Public
Version: author
License: Not specified
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_43F3EEE894DD
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Long-term Outcome after Liver Resection for Hepatocellular Carcinoma Larger than 10 cm.
Journal
World Journal of Surgery
Author(s)
Allemann P., Demartines N., Bouzourene H., Tempia A., Halkic N.
ISSN
1432-2323 (Electronic)
ISSN-L
0364-2313
Publication state
Published
Issued date
2013
Volume
37
Number
2
Pages
452-458
Language
english
Notes
Publication types: Journal Article Publication Status: ppublishPDF type: article
Abstract
BACKGROUND: The purpose of the present study was to analyze long-term survival and disease-free survival after liver resection for giant hepatocellular carcinoma (HCC) ≥ 10 cm compared to HCC < 10 cm in diameter. The surgical approach in the treatment of giant HCC may achieve long-term survival and disease-free survival comparable to treatment of smaller lesions.
METHODS: This retrospective analysis was a monocentric study conducted in a tertiary university center. It included 101 patients from 114 consecutive liver resections for HCC, separated into two groups: those with tumors less than 10 cm in diameter (small HCC; n = 79) and those with tumors larger than 10 cm (giant HCC; n = 22). The main outcome measures were overall five-year survival, five-year disease-free survival, recurrence rate, perioperative mortality at 30 days, surgical complication rate, and re-intervention rate.
RESULTS: The two groups were homogeneously distributed, apart from cirrhosis, which was found more frequently in the group with small HCC (77 vs. 41 %; p = 0.0013). Both median survival (24 vs. 27 months; p = 0.0085) and overall 5-year survival (21 vs. 45; p = 0.04) were significantly poorer in the small HCC group compared to the giant HCC group. There were no differences en terms of recurrence rate, pattern, and timing.
CONCLUSIONS: Liver resection for HCC larger than 10 cm is a valuable option in selected patients, one that provides overall survival and disease-free survival comparable to smaller lesions. Functional reserves of the liver, more than the size of the lesion, may be important in patient selection for surgical resection.
Pubmed
Web of science
Open Access
Yes
Create date
06/02/2013 11:56
Last modification date
01/10/2019 7:17
Usage data