A cellular system for spatial signal decoding in chemical gradients.

Details

Serval ID
serval:BIB_43C973401A93
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A cellular system for spatial signal decoding in chemical gradients.
Journal
Developmental Cell
Author(s)
Hegemann B., Unger M., Lee S.S., Stoffel-Studer I., van den Heuvel J., Pelet S., Koeppl H., Peter M.
ISSN
1878-1551 (Electronic)
ISSN-L
1534-5807
Publication state
Published
Issued date
2015
Volume
35
Number
4
Pages
458-470
Language
english
Abstract
Directional cell growth requires that cells read and interpret shallow chemical gradients, but how the gradient directional information is identified remains elusive. We use single-cell analysis and mathematical modeling to define the cellular gradient decoding network in yeast. Our results demonstrate that the spatial information of the gradient signal is read locally within the polarity site complex using double-positive feedback between the GTPase Cdc42 and trafficking of the receptor Ste2. Spatial decoding critically depends on low Cdc42 activity, which is maintained by the MAPK Fus3 through sequestration of the Cdc42 activator Cdc24. Deregulated Cdc42 or Ste2 trafficking prevents gradient decoding and leads to mis-oriented growth. Our work discovers how a conserved set of components assembles a network integrating signal intensity and directionality to decode the spatial information contained in chemical gradients.
Pubmed
Web of science
Open Access
Yes
Create date
11/12/2015 8:42
Last modification date
20/08/2019 13:47
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