Densitometric regional ejection fraction: a new three-dimensional index of regional left ventricular function--comparison with geometric methods

Details

Serval ID
serval:BIB_43C080F013AB
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Densitometric regional ejection fraction: a new three-dimensional index of regional left ventricular function--comparison with geometric methods
Journal
Journal of the American College of Cardiology
Author(s)
Chappuis  F. P., Widmann  T. F., Nicod  P., Peterson  K. L.
ISSN
0735-1097 (Print)
Publication state
Published
Issued date
01/1988
Volume
11
Number
1
Pages
72-82
Notes
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Jan
Abstract
Densitometric regional ejection fraction obtained by computer analysis of digital subtraction ventriculography was evaluated as a new, quantitative, three-dimensional index of regional left ventricular performance. Eighteen patients with coronary artery disease and seven control subjects had right anterior oblique ventriculography at rest and immediately after rapid atrial pacing using central venous injection of contrast material. Regional left ventricular ejection fraction was determined by densitometry in six segments drawn around the end-diastolic center of gravity, and compared with two conventional indexes of segmental wall motion: area and radial regional ejection fraction. Densitometric, area or radial regional ejection fraction was classified as abnormal if it fell at least 2 standard deviations below the corresponding mean value in the normal group. The densitometric method did not require outlining of the end-systolic left ventricular silhouette and was the easiest and fastest to perform of all three techniques. In addition, intra- and interobserver reproducibilities were higher with the densitometric method (r = 0.97 and 0.95) than with either the area (r = 0.84 and 0.82) or the radial method (r = 0.82 and 0.76). Regional left ventricular dysfunction as assessed by the densitometric, area and radial techniques allowed the detection of coronary artery disease in 50, 50 and 44% of the patients at rest and in 83, 67 and 61% of the patients in the post-pacing period, respectively. Post-pacing regional left ventricular dysfunction accurately predicted the presence or absence of greater than 70% diameter stenosis in the supplying coronary artery in 75, 67 and 56% of the cases, respectively. Thus, densitometric analysis of digital subtraction ventriculography allows a fast and reproducible three-dimensional determination of regional left ventricular ejection fraction. Using this technique, pacing-induced regional dysfunction can be detected in most patients with coronary artery disease and corresponds well with the location of significant coronary artery lesions.
Keywords
Cardiac Pacing, Artificial Contrast Media Coronary Disease/*radiography Densitometry, X-Ray/*methods Diatrizoate/diagnostic use Diatrizoate Meglumine/diagnostic use Drug Combinations/diagnostic use Female Heart/*radiography Humans Male Middle Aged Radiographic Image Enhancement/*methods Reference Values *Stroke Volume Subtraction Technique
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 14:00
Last modification date
20/08/2019 13:47
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