Syringocystadenoma papilliferum: a study of potential tumor suppressor genes

Details

Serval ID
serval:BIB_4385FD25BBC1
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Syringocystadenoma papilliferum: a study of potential tumor suppressor genes
Journal
American Journal of Dermatopathology
Author(s)
Boni  R., Xin  H., Hohl  D., Panizzon  R., Burg  G.
ISSN
0193-1091 (Print)
Publication state
Published
Issued date
04/2001
Volume
23
Number
2
Pages
87-9
Notes
Journal Article --- Old month value: Apr
Abstract
Syringocystadenoma papilliferum (SP) is a benign tumor most commonly located on the scalp or face, which frequently arises from a nevus sebaceus (NS). Transition of SP to basal cell carcinoma (BCC) and, albeit rarely, to metastatic adenocarcinoma may occur. Allelic deletions of the human homologue of the drosophila patched gene (PTCH) occur in both NS and BCC. To search for genetic changes in SP, a microdissection-based genetic analysis using polymorphic markers at 9q22 (PTCH; D9S15, D9S303, D9S287, D9S252) as well as markers at 9p21 flanking the tumor suppressor gene p16 (IFNA, D9S171) was performed. Glandular epithelium consisting of two rows of cells as well as adjacent normal tissue or inflammatory infiltrates in the stroma, when present, was dissected and subjected to single-step DNA extraction and loss of heterozygosity (LOH) analysis. Two of 10 informative SP cases showed LOH at 9q22 (PTCH). Three of 7 informative SP cases showed allelic deletions at 9p21 (p16). Allelic loss at 9q22 is consistent with the clinical observation of transition of SP to BCC. The finding of frequent allelic loss at 9p21 is unlikely to be related to the rare transition of SP to metastatic adenocarcinoma. Our study supports the hypothesis of a gatekeeper role of the tumor suppressor gene p16 in a variety of benign and malignant tumors, including SP.
Keywords
Adenocarcinoma, Papillary/*genetics/pathology Adenoma, Sweat Gland/*genetics/pathology DNA, Neoplasm/analysis Dissection Genes, p16/*genetics Genetic Markers Humans Loss of Heterozygosity Micromanipulation Microsatellite Repeats Polymerase Chain Reaction Sweat Gland Neoplasms/*genetics/pathology
Pubmed
Web of science
Create date
25/01/2008 16:55
Last modification date
20/08/2019 13:47
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