Normal pressure hydrocephalus and cognitive impairment: The gait phenotype matters too.

Details

Serval ID
serval:BIB_437157395BCA
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Normal pressure hydrocephalus and cognitive impairment: The gait phenotype matters too.
Journal
European journal of neurology
Author(s)
Morel E., Lingenberg A., Armand S., Assal F., Allali G.
ISSN
1468-1331 (Electronic)
ISSN-L
1351-5101
Publication state
In Press
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
Idiopathic normal pressure hydrocephalus (iNPH) is a chronic neurological disease resulting in progressive gait and cognitive disorders. We investigated whether the gait phenotype is associated with the severity of cognitive deficits in iNPH.
This retrospective study recruited 88 patients (mean age = 76.18 ± 7.21 years, 42% female). Patients were initially referred for suspicion of iNPH and underwent a comprehensive analysis, including gait analysis and cognitive evaluation.
In this cohort (27% normal gait, 25% frontal gait, 16% parkinsonian gait, 27% other gait abnormalities), patients with parkinsonian and frontal gait had the lowest Mini-Mental State Examination (MMSE) scores and the slowest gait speed. Patients with normal gait had the highest MMSE scores and gait speed. Frontal gait was associated with lower MMSE score, even after adjusting for age, gender, comorbidities, white matter lesions, and education level (β = -0.221 [95% confidence interval (CI) = -3.718 to -0.150], p = 0.034). Normal gait was associated with the best MMSE scores, even after adjusting for the abovementioned variables (β = 0.231 [95% CI = 0.124-3.639], p = 0.036).
Gait phenotypes among iNPH patients are linked to global cognition as assessed with MMSE.
Keywords
clinical evaluation, cognition, cognitive disorders, gait, normal pressure hydrocephalus
Pubmed
Web of science
Open Access
Yes
Create date
13/05/2024 14:32
Last modification date
18/05/2024 6:59
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