Looking into digestive mixed neuroendocrine - nonneuroendocrine neoplasms: subtypes, prognosis, and predictive factors.

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State: Public
Version: Author's accepted manuscript
License: Not specified
Serval ID
serval:BIB_436A525F8130
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Looking into digestive mixed neuroendocrine - nonneuroendocrine neoplasms: subtypes, prognosis, and predictive factors.
Journal
Histopathology
Author(s)
Uccella S., La Rosa S.
ISSN
1365-2559 (Electronic)
ISSN-L
0309-0167
Publication state
Published
Issued date
11/2020
Peer-reviewed
Oui
Volume
77
Number
5
Pages
700-717
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Mixed neuroendocrine - nonneuroendocrine neoplasms (MiNENs) of the digestive system represent a challenge for both pathologists and clinicians. Their nomenclature has changed several times, and their diagnostic criteria, classification and clinical behaviour have been matter of debate over the years. Although several attempts have been made to elucidate the pathogenesis and biology of MiNENs, some issues remain open. This review will provide: a historical background that helps in understanding the evolution of the concept and nomenclature of mixed neoplasms; a revision of the knowledge on this topic, including molecular aspects, to give the reader a comprehensive and practical overview on this challenging field of pathology; a focus on the diagnostic criteria and on the determination of prognostic and predictive factors; and a description of the different tumour types in the different sites of origin.
Keywords
MANEC, MiNEN, classification, mixed neuroendocrine-non-neuroendocrine neoplasm, prognosis, mixed neuroendocrine and non-neuroendocrine neoplasm
Pubmed
Web of science
Create date
17/06/2020 15:36
Last modification date
07/11/2020 7:20
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