Assessment of adipose tissue metabolism by means of subcutaneous mircrodialysis in patients with sepsis of circulatory failure

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Serval ID
serval:BIB_43329
Type
PhD thesis: a PhD thesis.
Collection
Publications
Institution
Title
Assessment of adipose tissue metabolism by means of subcutaneous mircrodialysis in patients with sepsis of circulatory failure
Author(s)
Martinez A.
Director(s)
Chioléro R.
Institution details
Université de Lausanne, Faculté de biologie et médecine
Publication state
Accepted
Issued date
2005
Language
english
Number of pages
7
Notes
REROID:R003875164; Old school value: Université de Lausanne; autres auteurs: Bollmann M.-D., Revelly J.-P., Berger M., Cayeux C., Tappy L., Chioléro R.
Abstract
Summary:
To evaluate the role of adipose tissue in the metabolic stress response of critically ill patients, the release of glycerol and lactate by subcutaneous adipose tissue was assessed by means of microdialysis in patients with sepsis or circulatory failure and in healthy subjects. Patients with sepsis had lower plasma free fatty acid concentrations and non-significant elevations of plasma glycerol concentrations, but higher adipose-systemic glycerol concentrations gradients than healthy subjects or patients with circulatory failure, indicating a stimulation of subcutaneous adipose lipolysis. They also had a higher lipid oxidation. Lipid metabolism (adipose-systemic glycerol gradients, lipid oxidation) was not altered in patients with circulatory failure. These observations highlight major differences in lipolysis and lipid utilization between patients with sepsis and circulatory failure. Hyperlactataemia was present in both groups of patients, but the adipose-systemic lactate concentration gradient was not increased, indicating that lactate production by adipose tissue was not involved. This speaks against a role of adipose tissue in the development of hyperlactataemia in critically ill patients.
Keywords
lactate production, lipid oxidation, lipolysis, shock
Create date
19/11/2007 13:40
Last modification date
20/08/2019 14:46
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